NCOA1
gen de la especie Homo sapiens
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El coactivador de receptor nuclear 1 (NCOA1 o SRC-1) es una proteína codificada en humanos por el gen HGNC NCOA1 .
Datos rápidos Coactivador de receptor nuclear 1, Estructuras disponibles ...
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La proteínas NCOA1 es un corregulador transcripcional que contiene varios dominios de interacción con receptores nucleares y una actividad histona acetiltransferasa intrínseca. NCOA1 es reclutado hacia ciertos promotores del ADN por receptores nucleares activados por ligando. Esta proteína acila histonas promoviendo que al ADN sea más accesible a la transcripción. De hecho, NCOA1 ayuda a los receptores nucleares en la activación de la expresión génica.[1][2]
La proteína NCOA1 ha demostrado ser capaz de interaccionar con:
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Lee, S K; Kim H J, Na S Y, Kim T S, Choi H S, Im S Y, Lee J W (Jul. de 1998). «Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits». J. Biol. Chem. (UNITED STATES) 273 (27): 16651-4. ISSN 0021-9258. PMID 9642216. Litterst, Claudia M; Pfitzner Edith (Sep. de 2002). «An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1». J. Biol. Chem. (United States) 277 (39): 36052-60. ISSN 0021-9258. PMID 12138096. doi:10.1074/jbc.M203556200. Spencer, T E; Jenster G, Burcin M M, Allis C D, Zhou J, Mizzen C A, McKenna N J, Onate S A, Tsai S Y, Tsai M J, O'Malley B W (Sep. de 1997). «Steroid receptor coactivator-1 is a histone acetyltransferase». Nature (ENGLAND) 389 (6647): 194-8. ISSN 0028-0836. PMID 9296499. doi:10.1038/38304. 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