SUFU

SUFU
Estructuras disponibles
PDB	Búsqueda ortóloga: PDBe RCSB
Lista de codigos id de PDB
	1M1L, 4BL8, 4BL9, 4BLA, 4BLB, 4BLD, 4KM8, 4KM9, 4KMD, 4KMH
Identificadores
Alias	SUFU, PRO1280, SUFUH, SUFUXL, SUFU negative regulator of hedgehog signaling, JBTS32
IDs externos	OMIM: 607035 MGI: 1345643 HomoloGene: 9262 GeneCards: SUFU
Enfermedades genéticamente relacionadas
	Joubert syndrome 32, cerebellar medulloblastoma
Ontología génica
Función molecular	• beta-catenin binding; • GO:0001106 transcription corepressor activity; • transcription factor binding; • signal transducer activity; • GO:0001948, GO:0016582 unión a proteína plasmática; • protein kinase binding;
Componente celular	• citosol; • cilio; • ciliary base; • ciliary tip; • núcleo celular; • citoplasma;
Proceso biológico	• desarrollo del esqueleto; • GO:0009373 regulation of transcription, DNA-templated; • ventricular septum development; • smoothened signaling pathway involved in ventral spinal cord interneuron specification; • negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; • spinal cord dorsal/ventral patterning; • GO:1901227 negative regulation of transcription by RNA polymerase II; • coronary vasculature development; • negative regulation of DNA-binding transcription factor activity; • negative regulation of osteoblast differentiation; • proteólisis; • heart looping; • aorta development; • neural tube closure; • determination of left/right symmetry; • smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; • negative regulation of ubiquitin-dependent protein catabolic process; • GO:0072468 transducción de señal; • skin development; • desarrollo de organismo multicelular; • cytoplasmic sequestering of transcription factor; • negative regulation of protein import into nucleus; • negative regulation of smoothened signaling pathway;
	Fuentes: Amigo / QuickGO
Patrón de la expressión del ARN
	Más referencias a datos de expressión
Ortólogos
	51684
	24069
	ENSG00000107882
	ENSMUSG00000025231
	Q9UMX1
	Q9Z0P7
	NM_001178133; NM_016169
	NM_001025391; NM_015752
	NP_001171604; NP_057253
	NP_001020562; NP_056567
	Wikidata
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