Interleukine 1 bêta

IL1B
	Structure d'IL-1b créée à l'aide des données de Protein Data Bank (PDB : 31BI)
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	1HIB, 1I1B, 1IOB, 1ITB, 1L2H, 1S0L, 1T4Q, 1TOO, 1TP0, 1TWE, 1TWM, 21BI, 2I1B, 2KH2, 2NVH, 31BI, 3O4O, 3POK, 41BI, 4DEP, 4G6J, 4G6M, 4GAI, 4I1B, 5I1B, 6I1B, 7I1B, 9ILB, 4GAF, 5BVP
Identifiants
Alias	IL1B, Interleukine 1 bêta
IDs externes	OMIM: 147720 MGI: 96543 HomoloGene: 481 GeneCards: IL1B
Position du gène (humain)
Chr.	Chromosome 2 humain
Fin	112,836,816 bp
Position du gène (souris)
Chr.	Chromosome 2 (souris)
Fin	129,213,059 bp
Expression génique
	Fortement exprimé dans
	ligament alvéolo-dentaire; ; granulocyte; ; monocyte; ; sang; ; cellule de la moelle osseuse; ; cartilage tissue; ; pancreatic ductal cell; ; vésicule biliaire; ; appendice iléo-cæcal; ; Caduque basale;
	Fortement exprimé dans
	granulocyte; ; sang; ; tibiofemoral joint; ; rate; ; embryon; ; moelle osseuse; ; îlot de Langerhans; ; poumon droit; ; lumbar subsegment of spinal cord; ; ventricule droit;
	Plus de données d'expression de référence
	; ;
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	protein domain specific binding; interleukin-1 receptor binding; cytokine activity; integrin binding; liaison protéique;
Composant cellulaire	cytoplasme; cytosol; région extracellulaire; lysosome; exosome; secretory granule; vésicule; milieu extracellulaire;
Processus biologique	positive regulation of protein phosphorylation; smooth muscle adaptation; positive regulation of calcidiol 1-monooxygenase activity; negative regulation of insulin receptor signaling pathway; cellular response to mechanical stimulus; positive regulation of interleukin-8 production; positive regulation of mitotic nuclear division; response to carbohydrate; implantation de l'embryon; regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of cell population proliferation; apoptose; cellular response to organic substance; positive regulation of phagocytosis; regulation of insulin secretion; neutrophil chemotaxis; régulation positive de la transcription dépendante de l'ADN; positive regulation of protein export from nucleus; positive regulation of prostaglandin secretion; positive regulation of myosin light chain kinase activity; negative regulation of MAP kinase activity; positive regulation of T cell proliferation; positive regulation of interleukin-6 production; réponse inflammatoire; negative regulation of lipid metabolic process; sequestering of triglyceride; hyaluronan biosynthetic process; positive regulation of heterotypic cell-cell adhesion; positive regulation of lipid catabolic process; cellular response to organic cyclic compound; positive regulation of fever generation; positive regulation of DNA-binding transcription factor activity; positive regulation of angiogenesis; response to lipopolysaccharide; positive regulation of NF-kappaB transcription factor activity; positive regulation of granulocyte macrophage colony-stimulating factor production; réponse immunitaire; ectopic germ cell programmed cell death; leukocyte migration; lipopolysaccharide-mediated signaling pathway; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of cell adhesion molecule production; response to ATP; monocyte aggregation; protein kinase B signaling; positive regulation of nitric oxide biosynthetic process; cell-cell signaling; positive regulation of monocyte chemotactic protein-1 production; regulation of nitric-oxide synthase activity; positive regulation of membrane protein ectodomain proteolysis; positive regulation of interferon-gamma production; MAPK cascade; positive regulation of histone acetylation; positive regulation of gene expression; negative regulation of glucose transmembrane transport; interleukin-1 beta production; positive regulation of T cell mediated immunity; extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of vascular endothelial growth factor production; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of lipid catabolic process; negative regulation of adiponectin secretion; regulation of establishment of endothelial barrier; positive regulation of cell division; transduction de signal; positive regulation of transcription by RNA polymerase II; cytokine-mediated signaling pathway; regulation of defense response to virus by host; fever generation; positive regulation of JNK cascade; positive regulation of cell population proliferation; regulation of signaling receptor activity; positive regulation of epithelial to mesenchymal transition; positive regulation of cell migration; interleukin-6 production; astrocyte activation; régulation de la neurogenèse; negative regulation of neurogenesis; negative regulation of synaptic transmission; positive regulation of glial cell proliferation; regulation of ERK1 and ERK2 cascade; interleukin-1-mediated signaling pathway; cellular response to lipopolysaccharide; positive regulation of neuroinflammatory response; positive regulation of p38MAPK cascade; positive regulation of NIK/NF-kappaB signaling; positive regulation of T-helper 1 cell cytokine production; positive regulation of prostaglandin biosynthetic process; positive regulation of complement activation; positive regulation of inflammatory response; response to interleukin-1; positive regulation of RNA biosynthetic process;
	Sources:Amigo / QuickGO
Orthologues
	3553
	16176
	ENSG00000125538
	ENSMUSG00000027398
	P01584
	P10749
	NM_000576
	NM_008361
	NP_000567
	NP_032387
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

L'interleukine 1 bêta est une isoforme de l'interleukine 1. Elle a un rôle pro-inflammatoire. Son gène est IL1B situé sur le chromosome 2 humain.