Janus-kinase 1

JAK1
	Structure de la protéine JAK1. Basée sur l'identifiant PDB 3EYG.
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	3EYG, 3EYH, 4E4L, 4E4N, 4E5W, 4EHZ, 4EI4, 4FK6, 4I5C, 4IVB, 4IVC, 4IVD, 4K6Z, 4K77, 4L00, 4L01, 5E1E, 5HX8, 5IXD, 5IXI
Identifiants
Alias	JAK1, Janus kinase 1
IDs externes	OMIM: 147795 MGI: 96628 HomoloGene: 1678 GeneCards: JAK1
Position du gène (humain)
Chr.	Chromosome 1 humain
Fin	65,067,754 bp
Position du gène (souris)
Chr.	Chromosome 4 (souris)
Fin	101,265,282 bp
Expression génique
	Fortement exprimé dans
	cellule bêta; ; skin of hip; ; tendon calcanéen; ; epithelium of nasopharynx; ; ganglion lymphatique; ; cartilage tissue; ; artère temporale superficielle; ; skin of thigh; ; parietal pleura; ; muscle glutéal;
	Fortement exprimé dans
	tibiofemoral joint; ; gastrula; ; ganglion lymphatique; ; muscle triceps brachial; ; granulocyte; ; ganglion mésentérique; ; cheville; ; muscle sterno-cléido-mastoïdien; ; sang; ; muscle temporal;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	activité de transférase; liaison nucléotide; protein kinase activity; CCR5 chemokine receptor binding; growth hormone receptor binding; liaison ion métal; activité kinase; liaison protéique; protein tyrosine kinase activity; protein phosphatase binding; signaling receptor binding; liaison ATP; ubiquitin protein ligase binding; non-membrane spanning protein tyrosine kinase activity;
Composant cellulaire	cytoplasme; cytosol; membrane; focal adhesion; extrinsic component of cytoplasmic side of plasma membrane; cytosquelette; système endomembranaire; noyau; endosome;
Processus biologique	différenciation cellulaire; intracellular signal transduction; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; interferon-gamma-mediated signaling pathway; response to antibiotic; MAPK cascade; positive regulation of sprouting angiogenesis; phosphorylation des protéines; regulation of type I interferon-mediated signaling pathway; regulation of interferon-gamma-mediated signaling pathway; regulation of cell population proliferation; type I interferon signaling pathway; interleukin-2-mediated signaling pathway; peptidyl-tyrosine autophosphorylation; protein autophosphorylation; migration cellulaire; système immunitaire inné; interleukin-12-mediated signaling pathway; interleukin-7-mediated signaling pathway; interleukin-15-mediated signaling pathway; interleukin-9-mediated signaling pathway; regulation of molecular function; peptidyl-tyrosine phosphorylation; cytokine-mediated signaling pathway; interleukin-21-mediated signaling pathway; interleukin-6-mediated signaling pathway; interleukin-27-mediated signaling pathway; interleukin-35-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologues
	3716
	16451
	ENSG00000162434
	ENSMUSG00000028530
	P23458
	P52332
NM_002227; NM_001320923; NM_001321852; NM_001321853; NM_001321854;
	NM_001321855; NM_001321856; NM_001321857
	NM_146145; NM_013567
NP_001307852; NP_001308781; NP_001308782; NP_001308783; NP_001308784;
	NP_001308785; NP_001308786; NP_002218
	n/a
	Wikidata
Voir/Editer Humain	Voir/Editer Souris