NOD2

NOD2
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	5IRL, 5IRM, 5IRN
Identifiants
Alias	NOD2
IDs externes	OMIM: 605956 MGI: 2429397 HomoloGene: 11156 GeneCards: NOD2
Position du gène (humain)
Chr.	Chromosome 16 humain
Fin	50,734,041 bp
Position du gène (souris)
Chr.	Chromosome 8 (souris)
Fin	89,415,102 bp
Expression génique
	Fortement exprimé dans
	monocyte; ; granulocyte; ; sang; ; skin of leg; ; skin of abdomen; ; vulve; ; pénis humain; ; cartilage tissue; ; cellule de la moelle osseuse; ; vagin;
	Fortement exprimé dans
	granulocyte; ; secondary oocyte; ; primary oocyte; ; zygote; ; embryon; ; œsophage; ; zone of skin; ; lèvre; ; muscle quadriceps fémoral; ; duodénum;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	Hsp90 protein binding; liaison nucléotide; Hsp70 protein binding; liaison protéique; peptidoglycan binding; liaison enzymatique; actin binding; CARD domain binding; liaison ATP; protein kinase binding; muramyl dipeptide binding; liaison de complexe macromoléculaire;
Composant cellulaire	cytoplasme; cytosol; vésicule; membrane; membrane plasmique; surface cellulaire; basolateral plasma membrane; COP9 signalosome; cytosquelette; appareil de Golgi; mitochondrie; complexe macromoléculaire;
Processus biologique	positive regulation of prostaglandin-endoperoxide synthase activity; regulation of apoptotic process; réponse de défense; detection of biotic stimulus; cytokine production involved in immune response; positive regulation of cytokine production involved in inflammatory response; intracellular signal transduction; detection of muramyl dipeptide; positive regulation of interleukin-10 production; positive regulation of epithelial cell proliferation; processus du système immunitaire; positive regulation of oxidoreductase activity; response to muramyl dipeptide; positive regulation of prostaglandin-E synthase activity; positive regulation of JNK cascade; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of NIK/NF-kappaB signaling; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of gamma-delta T cell activation; cellular response to muramyl dipeptide; JNK cascade; negative regulation of macrophage apoptotic process; positive regulation of dendritic cell antigen processing and presentation; nucleotide-binding oligomerization domain containing 2 signaling pathway; maintenance of gastrointestinal epithelium; defense response to bacterium; positive regulation of NF-kappaB transcription factor activity; positive regulation of interleukin-8 production; detection of bacterium; positive regulation of interleukin-1 beta production; regulation of inflammatory response; positive regulation of interleukin-6 production; protein complex oligomerization; positive regulation of tumor necrosis factor production; positive regulation of ERK1 and ERK2 cascade; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of B cell activation; positive regulation of interleukin-17 production; positive regulation of type 2 immune response; nucleotide-binding oligomerization domain containing signaling pathway; positive regulation of stress-activated MAPK cascade; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; cellular response to organic cyclic compound; positive regulation of cell population proliferation; système immunitaire inné; response to nutrient; positive regulation of dendritic cell cytokine production; positive regulation of protein K63-linked ubiquitination; cellular response to peptidoglycan; positive regulation of MAP kinase activity; interleukin-1-mediated signaling pathway; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologues
	64127
	257632
	ENSG00000167207
	ENSMUSG00000055994
	Q9HC29
	Q80SY9
	NM_001293557; NM_022162; NM_001370466
	NM_145857
	NP_001280486; NP_071445; NP_001357395
	NP_665856
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

NOD2 (« nucleotide-binding oligomerization domain 2 »), appelé également CARD15 (« caspase recruitment domain-containing protein 15 ») est une protéine constituant l'un des deux types de récepteur NOD. Son gène est le NOD2 situé sur le chromosome 16 humain.

PDBRecherche d'orthologue : PDBe RCSB

AliasNOD2

IDs externesOMIM: 605956 MGI: 2429397 HomoloGene: 11156 GeneCards: NOD2

Chr.Chromosome 16 humain^[1]

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