NPM1

NPM1
	Structure de la protéine NPM1. Basé sur l'identifiant PDB 2p1b.
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	2LLH, 2P1B, 2VXD
Identifiants
Alias	NPM1, B23, nucléophosmine (nucleolar phosphoprotein B23, numatrin), nucléophosmine
IDs externes	OMIM: 164040 MGI: 106184 HomoloGene: 81697 GeneCards: NPM1
Position du gène (humain)
Chr.	Chromosome 5 humain
Fin	171,411,810 bp
Position du gène (souris)
Chr.	Chromosome 11 (souris)
Fin	33,113,206 bp
Expression génique
	Fortement exprimé dans
	tendon calcanéen; ; left ovary; ; ventricular zone; ; right ovary; ; endocol; ; body of uterus; ; éminence ganglionnaire; ; body of pancreas; ; right uterine tube; ; ectocervix;
	Fortement exprimé dans
	tail of embryo; ; épiblaste; ; tubercule génital; ; morula; ; embryon; ; primary oocyte; ; zygote; ; secondary oocyte; ; embryon; ; blastocyste;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	ribosomal large subunit binding; protein homodimerization activity; ribosomal small subunit binding; unfolded protein binding; transcription coactivator activity; protein kinase inhibitor activity; histone binding; Tat protein binding; NF-kappaB binding; liaison protéique; liaison ARN; protein heterodimerization activity; Fixation d'acide nucléique; protein kinase binding; transcription factor binding; liaison ARNr; protein N-terminus binding; liaison de chromatine;
Composant cellulaire	cytoplasme; membrane; focal adhesion; spindle pole centrosome; nucléoplasme; centre organisateur des microtubules; nucléole; cytosquelette; noyau; protein-DNA complex; granular component; centrosome; cytosol; large ribosomal subunit; small ribosomal subunit; nuclear speck; complexe macromoléculaire; ribonucléoprotéine;
Processus biologique	centrosome cycle; regulation of eIF2 alpha phosphorylation by dsRNA; positive regulation of cell cycle G2/M phase transition; negative regulation of centrosome duplication; regulation of centriole replication; réponse au stress; positive regulation of translation; CENP-A containing chromatin assembly; régulation positive de la transcription dépendante de l'ADN; positive regulation of NF-kappaB transcription factor activity; protein complex oligomerization; negative regulation of protein kinase activity by regulation of protein phosphorylation; regulation of endodeoxyribonuclease activity; regulation of endoribonuclease activity; ribosome assembly; intracellular protein transport; réparation de l'ADN; transduction de signal; negative regulation of cell population proliferation; assemblage du nucléosome; viral process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of transcription by RNA polymerase II; cellular response to UV; ribosomal large subunit export from nucleus; ribosomal small subunit export from nucleus; rRNA export from nucleus; cell volume homeostasis; nucleocytoplasmic transport; protein localization; positive regulation of cell population proliferation; posttranscriptional regulation of gene expression; negative regulation of gene expression; regulation of centrosome duplication; positive regulation of centrosome duplication; croissance cellulaire; positive regulation of cellular biosynthetic process; positive regulation of protein ubiquitination; regulation of protein stability; ribosomal large subunit biogenesis; ribosomal small subunit biogenesis; negative regulation of apoptotic process; regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of protein kinase activity; positive regulation of transcription by RNA polymerase II; negative regulation of mRNA splicing, via spliceosome; protein stabilization; protein homooligomerization; régulation du cycle cellulaire; positive regulation of protein localization to nucleolus; Remodelage de la chromatine; regulation of mRNA stability involved in cellular response to UV;
	Sources:Amigo / QuickGO
Orthologues
	4869
	18148
	ENSG00000181163
	ENSMUSG00000057113
	P06748
	Q61937
NM_001037738; NM_002520; NM_199185; NM_001355006; NM_001355009;
	NM_001355007; NM_001355010
	NM_001252260; NM_001252261; NM_008722
NP_001032827; NP_002511; NP_954654; NP_001341935; NP_001341938;
	NP_001341936; NP_001341939
	NP_001239189; NP_001239190; NP_032748
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

La nucléophosmine, aussi appelée numatrine ou nucleolar phosphoprotéine B23, est une protéine codée par le gène NPM1, localisé sur le chromosome 5 humain.