PINK1

PINK1
Identifiants
Alias	PINK1, PTEN-induced putative kinase 1
IDs externes	OMIM: 608309 MGI: 1916193 HomoloGene: 32672 GeneCards: PINK1
Position du gène (humain)
Chr.	Chromosome 1 humain
Fin	20,651,511 bp
Position du gène (souris)
Chr.	Chromosome 4 (souris)
Fin	138,053,618 bp
Expression génique
	Fortement exprimé dans
	tendon of biceps brachii; ; muscle glutéal; ; muscle gastrocnémien; ; right frontal lobe; ; cortex préfrontal; ; amygdale; ; muscle de la cuisse; ; apex of heart; ; putamen; ; noyau accumbens;
	Fortement exprimé dans
	muscle de la cuisse; ; myocardium of ventricle; ; muscle intercostal; ; nerf ischiatique; ; muscle digastrique; ; muscle triceps brachial; ; cheville; ; muscle sterno-cléido-mastoïdien; ; muscle temporal; ; muscle extra-oculaire;
	Plus de données d'expression de référence
	; ;
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	C3HC4-type RING finger domain binding; activité kinase; liaison ATP; protein kinase activity; liaison ion métal; protein serine/threonine kinase activity; calcium-dependent protein kinase activity; peptidase activator activity; magnesium ion binding; activité de transférase; liaison de protéase; liaison protéique; liaison nucléotide; protein kinase B binding; ubiquitin protein ligase binding;
Composant cellulaire	cytoplasme; cytosol; membrane; mitochondrial intermembrane space; mitochondrie; perinuclear region of cytoplasm; cytosquelette; noyau; corps de Lewy; integral component of mitochondrial outer membrane; membrane mitochondrial externe; chromatine; TORC2 complex; integral component of membrane; ubiquitin ligase complex; mitochondrial outer membrane translocase complex; astrocyte projection; axone; cell body; membrane mitochondriale interne; cône de croissance;
Processus biologique	negative regulation of neuron apoptotic process; positive regulation of mitophagy in response to mitochondrial depolarization; positive regulation of free ubiquitin chain polymerization; regulation of protein ubiquitination; cellular response to toxic substance; positive regulation of catecholamine secretion; regulation of synaptic vesicle transport; positive regulation of translation; phosphorylation des protéines; positive regulation of dopamine secretion; macroautophagy; regulation of protein-containing complex assembly; cellular response to hypoxia; negative regulation of autophagosome assembly; positive regulation of protein kinase B signaling; positive regulation of protein dephosphorylation; ubiquitin-dependent protein catabolic process; peptidyl-serine autophosphorylation; regulation of neuron apoptotic process; response to oxidative stress; negative regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; negative regulation of mitochondrial fission; positive regulation of mitochondrial electron transport, NADH to ubiquinone; positive regulation of macroautophagy; regulation of autophagy of mitochondrion; positive regulation of ubiquitin-protein transferase activity; negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway; Ubiquitination; negative regulation of oxidative stress-induced cell death; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide; positive regulation of synaptic transmission, dopaminergic; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; regulation of oxidative phosphorylation; regulation of mitochondrion organization; regulation of hydrogen peroxide metabolic process; negative regulation of oxidative stress-induced neuron death; protein stabilization; mitochondrion organization; positive regulation of DNA-binding transcription factor activity; negative regulation of autophagy of mitochondrion; regulation of reactive oxygen species metabolic process; positive regulation of ATP biosynthetic process; maintenance of protein location in mitochondrion; regulation of protein targeting to mitochondrion; positive regulation of release of cytochrome c from mitochondria; chaîne de transport d'électrons respiratoire; positive regulation of protein ubiquitination; regulation of proteasomal protein catabolic process; activation of protein kinase B activity; intracellular signal transduction; negative regulation of macroautophagy; positive regulation of protein targeting to mitochondrion; positive regulation of cristae formation; positive regulation of peptidase activity; TORC2 signaling; regulation of mitochondrial membrane potential; autophagie; negative regulation of JNK cascade; establishment of protein localization to mitochondrion; mitophagie; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; cellular response to oxidative stress; negative regulation of reactive oxygen species metabolic process; negative regulation of apoptotic process; positive regulation of protein phosphorylation; positive regulation of histone deacetylase activity; mitochondrion to lysosome transport; regulation of cellular response to oxidative stress; response to ischemia; positive regulation of mitochondrial fission; positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization; cellular response to hydrogen sulfide; phosphorylation; negative regulation of neuron death; positive regulation of NMDA glutamate receptor activity; negative regulation of intrinsic apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologues
	65018
	68943
	ENSG00000158828
	ENSMUSG00000028756
	Q9BXM7
	Q99MQ3
	NM_032409
	NM_026880
	NP_115785
	NP_081156
	Wikidata
Voir/Editer Humain	Voir/Editer Souris