Profiline 1

PFN1
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	1AWI, 1CF0, 1CJF, 1FIK, 1FIL, 1PFL, 2PAV, 2PBD, 3CHW, 4X1L, 4X1M, 4X25
Identifiants
Alias	PFN1
IDs externes	OMIM: 176610 MGI: 97549 HomoloGene: 3684 GeneCards: PFN1
Position du gène (humain)
Chr.	Chromosome 17 humain
Fin	4,949,061 bp
Position du gène (souris)
Chr.	Chromosome 11 (souris)
Fin	70,545,470 bp
Expression génique
	Fortement exprimé dans
	granulocyte; ; mucosa of transverse colon; ; muscle layer of sigmoid colon; ; mucosa of ileum; ; monocyte; ; aorte thoracique; ; aorte ascendante; ; stromal cell of endometrium; ; Descending thoracic aorta; ; artère coronaire gauche;
	Fortement exprimé dans
	granulocyte; ; Vésicule vitelline; ; tail of embryo; ; thymus; ; tibiofemoral joint; ; ganglion lymphatique; ; ganglion mésentérique; ; tubercule génital; ; épiblaste; ; aorte ascendante;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	actin monomer binding; liaison protéique; adenyl-nucleotide exchange factor activity; actin binding; proline-rich region binding; liaison ARN; cadherin binding; signaling receptor binding; phosphatidylinositol-4,5-bisphosphate binding;
Composant cellulaire	cytosol; blood microparticle; membrane; focal adhesion; cortex cellulaire; exosome; cytosquelette; cytoplasme; noyau; milieu extracellulaire; neuron projection; synapse; glutamatergic synapse;
Processus biologique	positive regulation of actin filament polymerization; positive regulation of ATP-dependent activity; negative regulation of actin filament polymerization; positive regulation of ruffle assembly; regulation of transcription by RNA polymerase II; protein stabilization; positive regulation of epithelial cell migration; negative regulation of actin filament bundle assembly; neural tube closure; positive regulation of actin filament bundle assembly; negative regulation of stress fiber assembly; actin cytoskeleton organization; Wnt signaling pathway, planar cell polarity pathway; response to organic substance; positive regulation of transcription by RNA polymerase II; positive regulation of viral transcription; positive regulation of DNA metabolic process; positive regulation of stress fiber assembly; cellular response to growth factor stimulus; regulation of actin filament polymerization; synapse maturation; modification of postsynaptic actin cytoskeleton;
	Sources:Amigo / QuickGO
Orthologues
	5216
	18643
	ENSG00000108518
	ENSMUSG00000018293
	P07737
	P62962
	NM_005022; NM_001375991
	NM_011072
	NP_005013; NP_001362920
	NP_035202
	Wikidata
Voir/Editer Humain	Voir/Editer Souris