RYR2

RYR2
	Visualisation de la protéine Cristallisée RYR2
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	4JKQ
Identifiants
Alias	RYR2
IDs externes	OMIM: 180902 MGI: 99685 HomoloGene: 37423 GeneCards: RYR2
Position du gène (humain)
Chr.	Chromosome 1 humain
Fin	237,833,988 bp
Position du gène (souris)
Chr.	Chromosome 13 (souris)
Fin	12,106,945 bp
Expression génique
	Fortement exprimé dans
	ventricule droit; ; myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; apex of heart; ; auricule de l'oreillette droite; ; cellule endothéliale; ; Brodmann area 23; ; veine cave; ; primary visual cortex; ; right hemisphere of cerebellum;
	Fortement exprimé dans
	myocardium of ventricle; ; cardiac muscle tissue of left ventricle; ; ventricule droit; ; septum interventriculaire; ; atrium; ; valve auriculo-ventriculaire; ; lateral septal nucleus; ; gyrus denté; ; gyrus précentral; ; anterior amygdaloid area;
	Plus de données d'expression de référence
	n/a
Gene Ontology
Fonction moléculaire	transmembrane transporter binding; calcium channel activity; calcium-induced calcium release activity; protein kinase A catalytic subunit binding; liaison de composé organique cyclique; protein self-association; ion channel activity; liaison protéique; identical protein binding; liaison enzymatique; suramin binding; protein kinase A regulatory subunit binding; protein kinase binding; calcium-release channel activity; ryanodine-sensitive calcium-release channel activity; calcium liaison ionique; fixation de la calmoduline;
Composant cellulaire	integral component of membrane; canal calcique; membrane; sarcomère; junctional sarcoplasmic reticulum membrane; réticulum sarcoplasmique; Z discdkac; sarcoplasmic reticulum membrane; réticulum endoplasmique lisse; membrane plasmique; complexe macromoléculaire; membrane d'une vésicule cytoplasmique; sarcolemma;
Processus biologique	response to muscle stretch; release of sequestered calcium ion into cytosol; calcium ion transport into cytosol; regulation of cardiac conduction; regulation of cardiac muscle contraction by calcium ion signaling; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; response to hypoxia; cardiac muscle contraction; regulation of cytosolic calcium ion concentration; positive regulation of the force of heart contraction; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; cardiac muscle hypertrophy; ventricular cardiac muscle cell action potential; cell communication by electrical coupling involved in cardiac conduction; cellular calcium ion homeostasis; establishment of protein localization to endoplasmic reticulum; ion transport; BMP signaling pathway; left ventricular cardiac muscle tissue morphogenesis; regulation of heart rate; positive regulation of heart rate; detection of calcium ion; response to redox state; cellular response to epinephrine stimulus; développent d'un organisme multicellulaire; ion transmembrane transport; positive regulation of sequestering of calcium ion; embryonic heart tube morphogenesis; calcium ion transmembrane transport; cellular response to caffeine; sarcoplasmic reticulum calcium ion transport; canonical Wnt signaling pathway; regulation of SA node cell action potential; response to caffeine; regulation of cardiac muscle contraction; regulation of ventricular cardiac muscle cell action potential; regulation of AV node cell action potential; calcium-mediated signaling using intracellular calcium source; response to muscle activity; calcium ion transport; calcium-mediated signaling; type B pancreatic cell apoptotic process; regulation of atrial cardiac muscle cell action potential; positive regulation of ATPase-coupled calcium transmembrane transporter activity; Purkinje myocyte to ventricular cardiac muscle cell signaling; transport transmembranaire;
	Sources:Amigo / QuickGO
Orthologues
	6262
	20191
	ENSG00000198626
	ENSMUSG00000021313
	Q92736
	E9Q401
	NM_001035
	NM_023868
	NP_001026
	NP_076357
	Wikidata
Voir/Editer Humain	Voir/Editer Souris