ERBB4

ERBB4
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	2AHX, 2L2T, 2LCX, 2R4B, 3BBT, 3BBW, 3BCE, 3U2P, 3U7U, 3U9U
識別子
記号	ERBB4, ALS19, HER4, p180erbB4, erb-b2 receptor tyrosine kinase 4
外部ID	OMIM: 600543 MGI: 104771 HomoloGene: 21084 GeneCards: ERBB4
遺伝子の位置 (ヒト)
染色体	2番染色体 (ヒト)
終点	212,538,841 bp
遺伝子の位置 (マウス)
染色体	1番染色体 (マウス)
終点	69,147,218 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• トランスフェラーゼ活性; • ヌクレオチド結合; • protein kinase activity; • protein homodimerization activity; • epidermal growth factor receptor binding; • キナーゼ活性; • 血漿タンパク結合; • transmembrane receptor protein tyrosine kinase activity; • ATP binding; • protein tyrosine kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • 受容体型チロシンキナーゼ; • 膜貫通シグナル伝達受容体活性;
細胞の構成要素	• integral component of membrane; • 細胞質基質; • 膜; • receptor complex; • 細胞膜; • 核質; • 細胞外領域; • ミトコンドリアマトリックス; • basolateral plasma membrane; • ミトコンドリア; • 細胞核; • postsynaptic membrane; • glutamatergic synapse; • GABA-ergic synapse; • integral component of presynaptic membrane; • integral component of postsynaptic density membrane; • 細胞質; • integral component of plasma membrane; • basal plasma membrane;
生物学的プロセス	• mitochondrial fragmentation involved in apoptotic process; • negative regulation of neuron migration; • cell fate commitment; • positive regulation of protein phosphorylation; • regulation of cell migration; • regulation of transcription, DNA-templated; • olfactory bulb interneuron differentiation; • embryonic pattern specification; • リン酸化; • transmembrane receptor protein tyrosine kinase signaling pathway; • central nervous system morphogenesis; • mammary gland alveolus development; • transcription, DNA-templated; • 神経系発生; • mammary gland epithelial cell differentiation; • MAPK cascade; • positive regulation of phosphatidylinositol 3-kinase activity; • positive regulation of transcription, DNA-templated; • 多細胞個体の発生; • 心臓発生; • タンパク質リン酸化; • positive regulation of cardiac muscle cell proliferation; • neural crest cell migration; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of protein localization to cell surface; • 自己リン酸化; • cardiac muscle tissue regeneration; • positive regulation of phosphatidylinositol 3-kinase signaling; • peptidyl-tyrosine phosphorylation; • 授乳; • 細胞増殖; • 遊走; • シグナル伝達; • negative regulation of cell population proliferation; • アポトーシス; • ERBB2 signaling pathway; • phosphatidylinositol phosphate biosynthetic process; • peptidyl-tyrosine autophosphorylation; • positive regulation of cell population proliferation; • positive regulation of apoptotic process; • regulation of cell motility; • negative regulation of apoptotic process; • cellular response to epidermal growth factor stimulus; • positive regulation of tyrosine phosphorylation of STAT protein; • positive regulation of protein kinase B signaling; • positive regulation of receptor signaling pathway via JAK-STAT; • シナプス形成; • negative regulation of signal transduction; • 細胞分化;
	出典:Amigo / QuickGO
オルソログ
	2066
	13869
	ENSG00000178568
	ENSMUSG00000062209
	Q15303,H3BLT0
	Q61527
	NM_001042599; NM_005235
	NM_010154
	NP_001036064; NP_005226
	NP_034284
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス