HNF4A

HNF4A
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1PZL, 3CBB, 3FS1, 4B7W, 4IQR
識別子
記号	HNF4A, HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14, FRTS4, Hepatocyte nuclear factor 4 alpha, TCF-14
外部ID	OMIM: 600281 MGI: 109128 HomoloGene: 395 GeneCards: HNF4A
遺伝子の位置 (ヒト)
染色体	20番染色体 (ヒト)
終点	44,432,845 bp
遺伝子の位置 (マウス)
染色体	2番染色体 (マウス)
終点	163,414,830 bp
RNA発現パターン
	; ; ; ;
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• DNA結合; • sequence-specific DNA binding; • DNA-binding transcription factor activity; • DNA-binding transcription activator activity, RNA polymerase II-specific; • zinc ion binding; • 金属イオン結合; • steroid hormone receptor activity; • nuclear receptor activity; • 血漿タンパク結合; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • 受容体結合; • fatty acid binding; • protein homodimerization activity; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA-binding transcription factor activity, RNA polymerase II-specific;
細胞の構成要素	• 細胞核; • 細胞質; • 核質;
生物学的プロセス	• triglyceride homeostasis; • ornithine metabolic process; • phospholipid homeostasis; • regulation of transcription, DNA-templated; • SMAD protein signal transduction; • glucose homeostasis; • regulation of insulin secretion; • 脂質代謝; • regulation of transcription by RNA polymerase II; • signal transduction involved in regulation of gene expression; • sex differentiation; • 凝固・線溶系; • response to glucose; • transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • regulation of lipid metabolic process; • intracellular receptor signaling pathway; • regulation of growth hormone receptor signaling pathway; • negative regulation of cell growth; • 脂質恒常性; • 生体異物の代謝プロセス; • transcription initiation from RNA polymerase II promoter; • regulation of gastrulation; • steroid hormone mediated signaling pathway; • positive regulation of transcription by RNA polymerase II; • negative regulation of cell population proliferation; • cholesterol homeostasis; • type B pancreatic cell development; • hepatocyte differentiation; • regulation of circadian rhythm; • negative regulation of transcription, DNA-templated; • 周期的プロセス;
	出典:Amigo / QuickGO
オルソログ
	3172
	15378
	ENSG00000101076
	ENSMUSG00000017950
	P41235
	P49698
NM_000457; NM_001030003; NM_001030004; NM_001258355; NM_001287182;
	NM_001287183; NM_001287184; NM_175914; NM_178849; NM_178850
	NM_008261; NM_001312906; NM_001312907
NP_000448; NP_001025174; NP_001025175; NP_001245284; NP_001274111;
	NP_001274112; NP_001274113; NP_787110; NP_849180; NP_849181
	NP_001299835; NP_001299836; NP_032287
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

HNF4AまたはHNF4α（hepatocyte nuclear factor 4 alpha）、NR2A1（nuclear receptor subfamily 2, group A, member 1）は、ヒトではHNF4A遺伝子にコードされる核内受容体である^[5]^[6]。