LRP6

LRP6
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	3S2K, 3S8V, 3S8Z, 3S94, 3SOB, 3SOQ, 3SOV, 4A0P, 4DG6, 4NM5, 4NM7
識別子
記号	LRP6, ADCAD2, STHAG7, LDL receptor related protein 6
外部ID	OMIM: 603507 MGI: 1298218 HomoloGene: 1747 GeneCards: LRP6
遺伝子の位置 (ヒト)
染色体	12番染色体 (ヒト)
終点	12,267,044 bp
遺伝子の位置 (マウス)
染色体	6番染色体 (マウス)
終点	134,543,928 bp
RNA発現パターン
	; ;
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• low-density lipoprotein particle receptor activity; • apolipoprotein binding; • protein homodimerization activity; • kinase inhibitor activity; • frizzled binding; • Wnt-protein binding; • toxin transmembrane transporter activity; • 血漿タンパク結合; • coreceptor activity involved in Wnt signaling pathway; • identical protein binding; • Wnt-activated receptor activity; • 受容体結合; • coreceptor activity involved in canonical Wnt signaling pathway;
細胞の構成要素	• integral component of membrane; • Wnt-Frizzled-LRP5/6 complex; • Wnt signalosome; • ゴルジ体; • early endosome membrane; • 膜; • receptor complex; • シナプス; • 細胞外領域; • cell surface; • soma; • early endosome; • 小胞体; • カベオラ; • cytoplasmic vesicle; • 細胞膜; • 脂質ラフト;
生物学的プロセス	• negative regulation of protein phosphorylation; • Wnt signaling pathway involved in somitogenesis; • cerebellum morphogenesis; • roof of mouth development; • dopaminergic neuron differentiation; • positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; • regulation of transcription, DNA-templated; • エンドサイトーシス; • receptor-mediated endocytosis involved in cholesterol transport; • embryonic pattern specification; • 収斂伸長運動; • negative regulation of protein kinase activity; • 視床発生; • axis elongation involved in somitogenesis; • canonical Wnt signaling pathway involved in neural crest cell differentiation; • positive regulation of cytosolic calcium ion concentration; • response to peptide hormone; • canonical Wnt signaling pathway involved in regulation of cell proliferation; • neural crest cell differentiation; • positive regulation of DNA-binding transcription factor activity; • Wntシグナル経路; • cellular response to cholesterol; • neural crest formation; • trachea cartilage morphogenesis; • positive regulation of transcription, DNA-templated; • odontogenesis of dentin-containing tooth; • 多細胞個体の発生; • midbrain-hindbrain boundary development; • neural tube closure; • positive regulation of cell cycle; • external genitalia morphogenesis; • Wnt signaling pathway involved in dorsal/ventral axis specification; • pericardium morphogenesis; • 大脳皮質発生; • embryonic retina morphogenesis in camera-type eye; • canonical Wnt signaling pathway; • negative regulation of protein serine/threonine kinase activity; • protein localization to plasma membrane; • negative regulation of canonical Wnt signaling pathway; • negative regulation of smooth muscle cell apoptotic process; • face morphogenesis; • primitive streak formation; • positive regulation of transcription by RNA polymerase II; • 化学的シナプス伝達; • toxin transport; • Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; • positive regulation of canonical Wnt signaling pathway; • beta-catenin destruction complex disassembly; • midbrain dopaminergic neuron differentiation; • gastrulation with mouth forming second; • anterior/posterior pattern specification; • embryonic limb morphogenesis; • 中脳発生; • 骨再形成; • embryonic camera-type eye morphogenesis; • bone morphogenesis; • branching involved in mammary gland duct morphogenesis; • cell-cell adhesion;
	出典:Amigo / QuickGO
オルソログ
	4040
	16974
	ENSG00000070018; ENSG00000281324
	ENSMUSG00000030201
	O75581
	O88572
	NM_002336
	NM_008514
	NP_002327
	NP_032540
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

PDBオルソログ検索: RCSB PDBe PDBj

記号LRP6, ADCAD2, STHAG7, LDL receptor related protein 6

外部IDOMIM: 603507 MGI: 1298218 HomoloGene: 1747 GeneCards: LRP6

染色体12番染色体 (ヒト)^[1]

LRP6（low-density lipoprotein receptor-related protein 6）は、ヒトではLRP6遺伝子にコードされるタンパク質である^[5]^[6]。LRP6は古典的Wnt経路に関与するLRP5/LRP6/Frizzled受容体群の重要な構成要素である。

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[6]

LRP6

機能

相互作用

臨床的意義

出典

関連文献

Related Articles

Related Articles

“Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone”

“Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members”

“New Insights into Wnt-Lrp5/6-β-Catenin Signaling in Mechanotransduction”

“Regulation of Wnt/beta-catenin signaling within and from osteocytes”

“Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”

“A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.”

“Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.”

“The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”