P53遺伝子

TP53
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	4QO1, 1A1U, 1AIE, 1C26, 1DT7, 1GZH, 1H26, 1HS5, 1KZY, 1MA3, 1OLG, 1OLH, 1PES, 1PET, 1SAE, 1SAF, 1SAK, 1SAL, 1TSR, 1TUP, 1UOL, 1XQH, 1YC5, 1YCQ, 1YCR, 1YCS, 2AC0, 2ADY, 2AHI, 2ATA, 2B3G, 2BIM, 2BIN, 2BIO, 2BIP, 2BIQ, 2FEJ, 2FOJ, 2FOO, 2GS0, 2H1L, 2H2D, 2H2F, 2H4F, 2H4H, 2H4J, 2H59, 2J0Z, 2J10, 2J11, 2J1W, 2J1X, 2J1Y, 2J1Z, 2J20, 2J21, 2K8F, 2L14, 2LY4, 2MEJ, 2MWO, 2MWP, 2MZD, 2OCJ, 2PCX, 2RUK, 2VUK, 2WGX, 2X0U, 2X0V, 2X0W, 2XWR, 2YBG, 2YDR, 2Z5S, 2Z5T, 3D05, 3D06, 3D07, 3D08, 3D09, 3D0A, 3DAB, 3DAC, 3IGK, 3IGL, 3KMD, 3KZ8, 3LW1, 3OQ5, 3PDH, 3Q01, 3Q05, 3Q06, 3SAK, 3TG5, 3TS8, 3ZME, 4AGL, 4AGM, 4AGN, 4AGO, 4AGP, 4AGQ, 4BUZ, 4BV2, 4HFZ, 4HJE, 4IBQ, 4IBS, 4IBT, 4IBU, 4IBV, 4IBW, 4IBY, 4IBZ, 4IJT, 4KVP, 4LO9, 4LOE, 4LOF, 4MZI, 4MZR, 4X34, 4ZZJ, 5AOL, 5ABA, 5AOK, 2MWY, 5A7B, 5AOJ, 5AOI, 5ECG, 5AB9, 4FZ3, 4RP6, 4XR8, 5AOM, 4RP7, 5HOU, 5HP0, 5HPD, 5LGY, 5G4M, 5G4O, 5G4N, 5BUA
識別子
記号	TP53, BCC7, LFS1, P53, TRP53, tumor protein p53, BMFS5, Genes, p53
外部ID	OMIM: 191170 MGI: 98834 HomoloGene: 460 GeneCards: TP53
遺伝子の位置 (ヒト)
染色体	17番染色体 (ヒト)
終点	7,687,538 bp
遺伝子の位置 (マウス)
染色体	11番染色体 (マウス)
終点	69,482,699 bp
RNA発現パターン
	; ;
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• protein N-terminus binding; • DNA-binding transcription factor activity; • protein self-association; • core promoter sequence-specific DNA binding; • DNA-binding transcription factor activity, RNA polymerase II-specific; • protein phosphatase binding; • ATP binding; • 転写因子結合; • 金属イオン結合; • protein phosphatase 2A binding; • 酵素結合; • zinc ion binding; • クロマチン結合; • protease binding; • damaged DNA binding; • 血漿タンパク結合; • histone acetyltransferase binding; • 銅イオン結合; • プロテインキナーゼ結合; • シャペロン結合; • DNA-binding transcription activator activity, RNA polymerase II-specific; • receptor tyrosine kinase binding; • p53結合; • identical protein binding; • protein heterodimerization activity; • ubiquitin protein ligase binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • DNA結合; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • TFIID-class transcription factor complex binding; • mRNA 3'-UTR binding; • ヒストンデアセチラーゼ結合; • disordered domain specific binding; • promoter-specific chromatin binding; • histone deacetylase regulator activity; • protein homodimerization activity; • MDM2/MDM4 family protein binding;
細胞の構成要素	• 細胞質; • ミトコンドリア; • 細胞核; • 核内構造体; • TFIID; • 核マトリックス; • replication fork; • 核小体; • 小胞体; • 核質; • ミトコンドリアマトリックス; • PML body; • 細胞質基質; • 細胞内; • transcription regulator complex; • 高分子複合体; • site of double-strand break;
生物学的プロセス	• positive regulation of histone deacetylation; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • 周期的プロセス; • replicative senescence; • negative regulation of telomerase activity; • oligodendrocyte apoptotic process; • DNA損傷刺激に対する細胞応答; • intrinsic apoptotic signaling pathway; • positive regulation of neuron apoptotic process; • regulation of mitochondrial membrane permeability; • positive regulation of reactive oxygen species metabolic process; • cellular response to ionizing radiation; • positive regulation of thymocyte apoptotic process; • negative regulation of helicase activity; • 細胞周期; • Ras protein signal transduction; • 細胞増殖; • cellular response to hypoxia; • negative regulation of cell population proliferation; • ヌクレオチド除去修復; • cellular response to glucose starvation; • regulation of transcription, DNA-templated; • response to antibiotic; • transcription, DNA-templated; • ER overload response; • positive regulation of transcription, DNA-templated; • negative regulation of cell growth; • intrinsic apoptotic signaling pathway by p53 class mediator; • positive regulation of peptidyl-tyrosine phosphorylation; • viral process; • response to gamma radiation; • negative regulation of fibroblast proliferation; • positive regulation of intrinsic apoptotic signaling pathway; • 細胞分化; • determination of adult lifespan; • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; • cellular response to UV; • DNA damage response, signal transduction by p53 class mediator; • negative regulation of apoptotic process; • protein tetramerization; • oxidative stress-induced premature senescence; • positive regulation of release of cytochrome c from mitochondria; • circadian behavior; • negative regulation of transcription, DNA-templated; • タンパク質局在化; • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • positive regulation of execution phase of apoptosis; • 多細胞個体の発生; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • positive regulation of gene expression; • mitotic G1 DNA damage checkpoint signaling; • positive regulation of protein oligomerization; • positive regulation of apoptotic process; • entrainment of circadian clock by photoperiod; • response to X-ray; • positive regulation of transcription by RNA polymerase II; • base-excision repair; • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; • regulation of cell cycle G2/M phase transition; • proteasome-mediated ubiquitin-dependent protein catabolic process; • regulation of signal transduction by p53 class mediator; • アポトーシス; • transcription by RNA polymerase II; • positive regulation of protein export from nucleus; • プログラム細胞死; • regulation of apoptotic process; • protein deubiquitination; • phosphatidylinositol-mediated signaling; • negative regulation of transcription by RNA polymerase II; • オートファジー; • mRNA transcription; • サイトカイン媒介シグナル伝達経路; • positive regulation of RNA polymerase II transcription preinitiation complex assembly; • RNA polymerase II preinitiation complex assembly; • protein homotetramerization; • protein-containing complex assembly; • cellular response to gamma radiation; • signal transduction by p53 class mediator; • cellular response to actinomycin D; • positive regulation of pri-miRNA transcription by RNA polymerase II; • positive regulation of production of miRNAs involved in gene silencing by miRNA; • in utero embryonic development; • 体節形成; • release of cytochrome c from mitochondria; • hematopoietic progenitor cell differentiation; • T cell proliferation involved in immune response; • B cell lineage commitment; • T cell lineage commitment; • response to ischemia; • double-strand break repair; • regulation of transcription by RNA polymerase II; • protein import into nucleus; • 酸化ストレスへの反応; • transforming growth factor beta receptor signaling pathway; • 原腸形成; • negative regulation of neuroblast proliferation; • 中枢神経系発生; • 心臓発生; • 概日リズム; • negative regulation of DNA replication; • rRNA transcription; • response to UV; • response to salt stress; • embryo development ending in birth or egg hatching; • 遺伝子発現の負の調節; • positive regulation of cardiac muscle cell apoptotic process; • 小脳発生; • negative regulation of transforming growth factor beta receptor signaling pathway; • T cell differentiation in thymus; • regulation of tissue remodeling; • multicellular organism growth; • positive regulation of mitochondrial membrane permeability; • positive regulation of transcription from RNA polymerase II promoter in response to stress; • regulation of cell population proliferation; • mitochondrial DNA repair; • regulation of DNA damage response, signal transduction by p53 class mediator; • regulation of neuron apoptotic process; • negative regulation of proteolysis; • negative regulation of mitotic cell cycle; • 骨髄の発生; • embryonic organ development; • タンパク質の安定化; • 染色体構成; • neuron apoptotic process; • regulation of cell cycle; • hematopoietic stem cell differentiation; • interferon-gamma-mediated signaling pathway; • cardiac septum morphogenesis; • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; • positive regulation of programmed necrotic cell death; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • regulation of thymocyte apoptotic process; • ネクロトーシス（またはネクロプトーシス）; • cellular response to UV-C; • negative regulation of mitophagy; • regulation of mitochondrial membrane permeability involved in apoptotic process; • regulation of intrinsic apoptotic signaling pathway by p53 class mediator; • negative regulation of production of miRNAs involved in gene silencing by miRNA; • negative regulation of glucose catabolic process to lactate via pyruvate; • intrinsic apoptotic signaling pathway in response to hypoxia; • regulation of fibroblast apoptotic process; • negative regulation of reactive oxygen species metabolic process; • regulation of cellular senescence;
	出典:Amigo / QuickGO
オルソログ
	7157
	22059
	ENSG00000141510
	ENSMUSG00000059552
	P04637
	P02340
NM_001276761; NM_000546; NM_001126112; NM_001126113; NM_001126114;
	NM_001126115; NM_001126116; NM_001126117; NM_001126118; NM_001276695; NM_001276696; NM_001276697; NM_001276698; NM_001276699; NM_001276760
	NM_001127233; NM_011640
NP_000537; NP_001119584; NP_001119585; NP_001119586; NP_001119587;
	NP_001119588; NP_001119589; NP_001119590; NP_001263624; NP_001263625; NP_001263626; NP_001263627; NP_001263628; NP_001263689; NP_001263690
	NP_001120705; NP_035770
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

p53遺伝子（ピー53いでんし）とは、一つ一つの細胞内でDNA修復や細胞増殖停止、アポトーシスなどの細胞増殖サイクルの抑制を制御する機能を持ち、細胞ががん化したときアポトーシスを起こさせるとされる。この遺伝子による機能が不全となるとがんが起こると考えられている、いわゆる癌抑制遺伝子の一つ。

PDBオルソログ検索: RCSB PDBe PDBj

記号TP53, BCC7, LFS1, P53, TRP53, tumor protein p53, BMFS5, Genes, p53

外部IDOMIM: 191170 MGI: 98834 HomoloGene: 460 GeneCards: TP53

染色体17番染色体 (ヒト)^[1]

概要 TP53, PDBに登録されている構造 ...

閉じる

p53のpはタンパク質（protein）、53は分子量53,000を意味し、その遺伝子産物であるp53タンパク質（以下単にp53）は393個のアミノ酸から構成されている。この遺伝子は進化的に保存されており、昆虫や軟体動物にも存在している。ただしそれらのアミノ酸一次配列はかなり多様化している。またパラログとしてp63やp73もある。RB遺伝子とともによく知られている。

細胞が、がん化するためには複数の癌遺伝子と癌抑制遺伝子の変化が必要らしいことが分かっているが、p53遺伝子は悪性腫瘍（癌）において最も高頻度に異常が認められている。p53は、細胞の恒常性の維持やアポトーシス誘導といった重要な役割を持つことから「ゲノムの守護者 (The Guardian of the genome)」とも表現されるが、染色体構造が変化する機構と、それらの細胞内での働き、そしてそれらが生物にとってどのように大切なのかについてはよくわかっていない。

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P53遺伝子

遺伝子座

研究史

機能

変異

遺伝子治療

Li-Fraumeni症候群

脚注

出典

関連項目

外部リンク

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