13-Hydroxylergotrile

13-Hydroxylergotrile, also known as 2-chloro-6-methyl-13-hydroxyergoline-8β-acetonitrile, is a dopamine receptor agonist of the ergoline family.^[1][2] It is an active metabolite of the never-marketed antiparkinsonian agent lergotrile (LY-79907).^[1][2] The drug has been found to be 100-fold more potent as a dopamine receptor agonist than lergotrile itself in vitro.^[1][2] 13-Hydroxylergotrile was first described in the scientific literature by 1978.^[1]

Other names2-Chloro-6-methyl-13-hydroxyergoline-8β-acetonitrile

Drug classDopamine receptor agonist

ATC code

• None

FormulaC₁₇H₁₇ClN₃O

Quick facts Clinical data, Other names ...

13-Hydroxylergotrile

Clinical data
Other names	2-Chloro-6-methyl-13-hydroxyergoline-8β-acetonitrile
Drug class	Dopamine receptor agonist
ATC code	None
Chemical and physical data
Formula	C17H17ClN3O
Molar mass	314.79 g·mol−1
3D model (JSmol)	Interactive image
SMILES ClC1=C2C3C(=CC(O[H])=CC=3[C@]([H])3C[C@@](CC#N)CN(C)[C@]3([H])C2)N1[H]
InChI InChI=1S/C17H17ClN3O/c1-21-8-9(2-3-19)4-11-12-5-10(22)6-14-16(12)13(7-15(11)21)17(18)20-14/h5-6,11,15,20,22H,2,4,7-8H2,1H3/t11-,15-/m1/s1 Key:KFEUDMMGAVSBGW-IAQYHMDHSA-N

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