2-Me-DET
Chemical compound
From Wikipedia, the free encyclopedia
2-Me-DET, or 2-methyl-DET, also known as 2-methyl-N,N-diethyltryptamine, is a psychedelic drug of the tryptamine family.[1] It is the 2-methyl derivative of diethyltryptamine (DET).[1] The drug is taken orally.[1]
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| Other names | 2-Methyl-DET; 2-Methyl-N,N-diethyltryptamine |
| Routes of administration | Oral[1] |
| Drug class | Psychoactive drug; Serotonergic psychedelic; Hallucinogen |
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| Duration of action | 6–8 hours[1] |
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| Formula | C15H22N2 |
| Molar mass | 230.355 g·mol−1 |
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Use and effects
In his book TiHKAL (Tryptamines I Have Known and Loved), Alexander Shulgin lists 2-Me-DET's dose as 80 to 120 mg orally and its duration as 6 to 8 hours.[1] The effects of 2-Me-DET have been reported to include a vague unreal feeling, clouding and slowing of thoughts, DiPT-like sound distortion including higher pitches of music sounding muffled and tones shifting to a lower frequency, and stomach ache.[1]
Interactions
Pharmacology
Pharmacodynamics
2-Me-DET is a serotonin receptor agonist in the rat uterus and stomach strip, with similar potency as dimethyltryptamine (DMT) and diethyltryptamine (DET) but profoundly greater potency than 2-methyl-DMT.[2]
Chemistry
Synthesis
The chemical synthesis of 2-Me-DET has been described.[1]
Analogues
Analogues of 2-Me-DET include 2-methyltryptamine (2-MT; 2-Me-T), 2-methyl-DMT (2-Me-DMT; 2,N,N-TMT), 2-methyl-5-MeO-DMT (5-MeO-2,N,N-TMT), and 2-methyl-AMT (2-Me-AMT; 2,α-DMT).[1]
History
2-Me-DET was first described in the scientific literature by R. B. Barlow and I. Khan in 1959.[2] Subsequently, it was described in greater detail by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved).[1]