2-Phenyl-2-propanol
Chemical compound
From Wikipedia, the free encyclopedia
2-Phenyl-2-propanol is a chemical compound that belongs to the alcohol group. It is a derivative of cumene.
| |
| Names | |
|---|---|
| Preferred IUPAC name
2-Phenylpropan-2-ol | |
| Identifiers | |
3D model (JSmol) |
|
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.009.582 |
| EC Number |
|
PubChem CID |
|
| UNII | |
CompTox Dashboard (EPA) |
|
| |
| |
| Properties | |
| C9H12O | |
| Molar mass | 136.19 g/mol |
| Appearance | White to pale yellow odorless solid[1] |
| Density | 0.973 g/cm3[1] |
| Melting point | 28–32 °C (301–305 K)[1] |
| Boiling point | 202[1] °C (396 °F; 475 K) |
| Practically insoluble[2] | |
| Solubility | Soluble in ethanol and benzene[3] |
Refractive index (nD) |
1.49146 (20 °C)[4] |
| Hazards | |
| GHS labelling: | |
 [1] | |
| Danger | |
| H302, H315, H319 | |
| P280, P301+P330+P331, P302+P352, P305+P351+P338, P362[1] | |
| Lethal dose or concentration (LD, LC): | |
LD50 (median dose) |
4300mg/kg (rabbit, transdermal);[1] 1300mg/kg (rat, oral) [1] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
Synthesis
2-Phenyl-2-propanol can be synthesized through Grignard reaction between phenylmagnesium bromide and acetone.[5][6]
Properties
Applications
2-Phenyl-2-propanol can either be applied in organic syntheses, or be reactants or intermediates in agrochemical, medical, and dyestuff fields.[2]
2-Phenyl-2-propanol is the main metabolite of cumene, and therefore 2-phenyl-2-propanol can serve as a biomarker of cumene.[7]
Hazards
According to a report of Federal Institute for Risk Assessment in 2008, there is strong evidence that 2-phenyl-2-propanol may lead to allergic reactions for humans.[8]