3-Thioescaline
Pharmaceutical compound
From Wikipedia, the free encyclopedia
3-Thioescaline (3-TE), also known as 3-methoxy-4-ethoxy-5-methylthiophenethylamine, is a psychedelic drug of the phenethylamine and scaline families related to mescaline.[1][2][3][4] It is the analogue of escaline in which the methoxy group at the 3 position has been replaced with a methylthio group.[1][2][3][4] The drug is one of two possible thioescaline (TE) positional isomers, the other being 4-thioescaline (4-TE).[1][2][3][4]
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| Other names | 3-TE; 3-Methoxy-4-ethoxy-5-methylthiophenethylamine; 4-Ethoxy-3-methoxy-5-methylthiophenethylamine; 4-Ethoxy-5-methoxy-3-methylthiophenethylamine |
| Routes of administration | Oral[1] |
| Drug class | Serotonergic psychedelic; Hallucinogen |
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| Duration of action | 8–12 hours[1] |
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| Formula | C12H19NO2S |
| Molar mass | 241.35 g·mol−1 |
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In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 3-thioescaline's dose as 60 to 80 mg orally and its duration as 8 to 12 hours.[1][2][3] The drug has approximately 5 or 6 times the potency of mescaline.[2][3][4][1] The effects of 3-thioescaline have been reported to include closed-eye imagery and fantasy, sounds having a deeper pitch, introspection, enhanced appreciation of art and music, time dilation, body load, and sleep disturbances.[1] It was said to be psychedelic rather than just intoxicating.[1] The desired psychoactive effects were said to outweigh its physical side effects.[1]
The chemical synthesis of 3-thioescaline has been described.[1][4]
3-Thioescaline was first described in the scientific literature by Alexander Shulgin and Peyton Jacob III in 1984.[4] Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991.[1]