3-(Trifluoromethyl)aniline
Chemical compound
From Wikipedia, the free encyclopedia
3-(Trifluoromethyl)aniline is an organic compound with the formula CF3C6H4NH2. It is one of three isomers of trifluoromethylaniline. The corresponding N,N-dimethyl derivative is also known.[1]
| |
| Names | |
|---|---|
| Preferred IUPAC name
3-(Trifluoromethyl)aniline | |
| Other names
3-Aminobenzotrifluoride; m-ABTF; m-Trifluoromethylaniline, 3-(Trifluoromethyl)phenyl-1-amine | |
| Identifiers | |
3D model (JSmol) |
|
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.002.404 |
PubChem CID |
|
| UNII | |
CompTox Dashboard (EPA) |
|
| |
| |
| Properties | |
| C7H6F3N | |
| Molar mass | 161.12 g/mol |
| Appearance | colorless liquid |
| Density | 1.29 g/cm3 |
| Melting point | 5 to 6 °C (41 to 43 °F; 278 to 279 K) |
| Boiling point | 187 to 188 °C (369 to 370 °F; 460 to 461 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
Applications
3-Aminobenzotrifluoride is a versatile chemical intermediate with applications in the synthesis of the following list of compounds: 1. Atovaquone, 2. Colfenamate, 3. Etofenamate, 4. Floctafenine, 5. Flufenamic acid, 6. HT-2157, 7. Losulazine, 8. Morniflumate, 9. Niflumic acid, 10. Norflurazon, 11. Pentflutizide, 12. Prefenamate, 13. Salfluverine, 14. Talniflumate, 15. Triflocin, 16. Ticarbodine, 17. Ufenamate.
In addition, 3-aminobenzotrifluoride is used to synthesize 2-trifluoromethylphenothiazine [92-30-8]. This is used to synthesize: 1. Duoperone, 2. Homofenazine, 3. Trifluoperazine, 4. Oxaflumazine, 5. Fluacizine, 6. Trifluomeprazine, 7. Ciclofenazine.
4-Chloro-7-(trifluoromethyl)quinoline [346-55-4] is used to synthesize: 1. Antrafenine, 2. Antihyperquine, 3. Trifluoroquine [442-85-3], 4. EHT-1864, 5. Florifenine, 6. Losulazine.
