3-Aminopyridine
Chemical compound
From Wikipedia, the free encyclopedia
3-Aminopyridine is an aminopyridine. It is a colorless solid.[1]
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| Names | |
|---|---|
| Preferred IUPAC name
Pyridin-3-amine | |
| Other names
3-Pyridinamine; 3-Pyridylamine | |
| Identifiers | |
3D model (JSmol) |
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| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.006.658 |
| EC Number |
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PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C5H6N2 | |
| Molar mass | 94.117 g·mol−1 |
| Appearance | [citation needed] |
| Melting point | 65 °C (149 °F; 338 K) |
| Boiling point | 248 °C (478 °F; 521 K) |
| >1,000g/l | |
| Solubility in alcohol and benzene | Soluble[vague] |
| Hazards | |
| GHS labelling: | |
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| Danger | |
| H301, H311, H315, H319, H331, H335, H373 | |
| P260, P262, P264, P264+P265, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, P501 | |
| Flash point | 124 °C (255 °F; 397 K) |
| 628 °C (1,162 °F; 901 K) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Preparation
3-Aminopyridine is prepared by heating nicotinamide with sodium hypobromite (Hofmann rearrangement), which is in turn prepared in situ by the reaction of sodium hydroxide and bromine at 70 °C.[2]
It can be used in the synthesis of organic ligand 3-pyridylnicotinamide. Troxipide is another synthesis that uses 3-AP.