4-Methoxytryptamine
Pharmaceutical compound
From Wikipedia, the free encyclopedia
4-Methoxytryptamine (4-MeO-T; developmental code name PAL-548) is a serotonin receptor modulator of the tryptamine and 4-hydroxytryptamine families.[1] It is the O-methyl derivative of 4-hydroxytryptamine (4-HT) and a positional isomer of 5-methoxytryptamine and 6-methoxytryptamine.[1]
- None
 | |
 | |
| Clinical data | |
|---|---|
| Other names | 4-Methoxytryptamine; 4-Methoxy-T; 4-MeO-T; PAL-548; PAL548 |
| Drug class | Serotonin receptor modulator; Serotonin 5-HT2A receptor agonist |
| ATC code |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C11H14N2O |
| Molar mass | 190.246 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Pharmacology
The drug has been found to act as a potent serotonin 5-HT2A receptor full agonist, with an EC50 of 9.02 nM and an Emax of 108%.[1] It was inactive as a monoamine releasing agent, including of serotonin, norepinephrine, and dopamine, in rat brain synaptosomes (all EC50 = >10,000 nM), but was a very low-potency serotonin reuptake inhibitor (IC50 = 4,114 nM).[1]
History
4-Methoxytryptamine was first described in the scientific literature by at least 1962.[2]
