5-MeO-T-NBOMe
Chemical compound
From Wikipedia, the free encyclopedia
5-MeO-T-NBOMe, also known as 5MT-NBOMe or NBOMe-5-MeO-T, is a psychedelic drug of the tryptamine family related to the 25-NB (NBOMe) drugs.[1][2][3] It has been sold online as a designer drug.[3][1][2]
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| Other names | 5MT-NBOMe; NBOMe-5-MeO-T; 5-MeO-NBOMeT; N-(2-Methoxybenzyl)-5-methoxytryptamine |
| Drug class | Serotonin 5-HT2 receptor agonist; Serotonergic psychedelic; Hallucinogen |
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| Formula | C19H22N2O2 |
| Molar mass | 310.397 g·mol−1 |
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Use and effects
5-MeO-T-NBOMe is said to produce hallucinogenic effects in humans.[3]
Interactions
Pharmacology
Pharmacodynamics
5-MeO-T-NBOMe is a serotonin 5-HT2 receptor agonist and produces the head-twitch response in rodents.[1] However, compared to 25I-NBOMe, the drug is much less potent in producing the head-twitch response (~10-fold) and produces a much weaker maximal response (~25%).[1] 5-MeO-T-NBOMe is many times less potent than comparable phenethylamines such as 25C-NBOMe, but is still a reasonably potent and effective partial agonist for the 5-HT2 family of serotonin receptors.[1][2] A number of related compounds have also been developed, and in contrast to the phenethylamine counterparts the meta-substituted benzyl derivatives are in many cases more potent than the ortho-substituted benzyl compounds.[4]
Chemistry
Analogues
Analogues of 5-MeO-T-NBOMe include 5-methoxytryptamine (5-MT), N-benzyltryptamine (NBnT), 4-HO-NBnT, 5-MeO-NBnT, T-NBOMe, 5-MeO-T-NB3OMe, 5-MeO-NBpBrT, 5-MeO-N-DEAOP-NMT, and NEtPhOH-THPI, among others. It also shares structural similarities with pertines like oxypertine.
History
5-MeO-T-NBOMe was described by David E. Nichols and colleagues in 2015.[1] It was encountered online as a novel designer drug in 2023.[3]
Society and culture
Legal status
Canada
5-MeO-T-NBOMe is not a controlled substance in Canada as of 2025.[5]
United States
5-MeO-T-NBOMe is not an explicitly controlled substance in the United States.[6] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.