5,6-Dihydro-5(α-thyminyl)thymine
Chemical compound
From Wikipedia, the free encyclopedia
5,6-Dihydro-5(α-thyminyl)thymine is a DNA pyrimidine dimer photoproduct produced when DNA in bacterial spores is exposed to ultraviolet light.[1] In bacteria, this DNA base dimer deforms the structure of DNA, so endospore forming bacteria have an enzyme called spore photoproduct lyase that repairs this damage.[2]
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thymine.svg) | |
| Names | |
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| Preferred IUPAC name
5-[(5-Methyl-2,4-dioxo-1,3-diazinan-5-yl)methyl]pyrimidine-2,4(1H,3H)-dione | |
| Other names
5-Thyminyl-5,6-dihydrothymine | |
| Identifiers | |
3D model (JSmol) |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C10H12N4O4 | |
| Molar mass | 252.230 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Laboratory synthesis
5,6-Dihydro-5(α-thyminyl)thymine can also be synthesized in a laboratory by reacting 5-hydroxymethyluracil and 6-aminothymine yielding 5,6-dihydro-6-imino-5-(α-thyminyl)thymine. When hydrogen is added in a reduction then 5,6-dihydro-5(α-thyminyl)thymine is the product.[3]