7,8,3'-Trihydroxyflavone

7,8,3'-Trihydroxyflavone
Clinical data
Other names	7,8,3'-THF
ATC code	None;
Identifiers
	IUPAC name 7,8-Dihydroxy-2-(3-hydroxyphenyl)chromen-4-one;
CAS Number	137502-84-2;
PubChem CID	676310;
ChemSpider	589045;
UNII	F67B8S3MH9;
ChEMBL	ChEMBL225513;
CompTox Dashboard (EPA)	DTXSID00350274 ;
Chemical and physical data
Formula	C15H10O5
Molar mass	270.240 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC(=CC(=C1)O)C2=CC(=O)C3=C(O2)C(=C(C=C3)O)O;
	InChI InChI=1S/C15H10O5/c16-9-3-1-2-8(6-9)13-7-12(18)10-4-5-11(17)14(19)15(10)20-13/h1-7,16-17,19H; Key:ZJZSQGDOCUHCCW-UHFFFAOYSA-N;

7,8,3′-Trihydroxyflavone (7,8,3'-THF) is a flavone and small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF), that was derived from tropoflavin (7,8-DHF).^[1]^[2] Relative to tropoflavin, 7,8,3'-THF is 2–3-fold more potent in vitro as a TrkB agonist.^[1]^[2] 7,3'-Dihydroxyflavone (7,3'-DHF) is also more potent than tropoflavin in vitro, indicating that a 3'-hydroxy group on the B-ring enhances TrkB agonistic activity.^[1] 7,8,3'-THF has been tested in vivo and was found to produce TrkB-dependent neuroprotective effects in mice similarly to tropoflavin.^[2]^[3]