7-Dehydrocholesterol reductase
Mammalian protein found in humans
From Wikipedia, the free encyclopedia
7-Dehydrocholesterol reductase, also known as DHCR7, is a protein that in humans is encoded by the DHCR7 gene.[5][6][7]
Function
The protein encoded by this gene is an enzyme catalyzing the reversible production of cholesterol from 7-dehydrocholesterol using nicotinamide adenine dinucleotide phosphate (NADPH) as its cofactor.[8]
The DHCR7 gene encodes delta-7-sterol reductase (EC 1.3.1.21), the ultimate enzyme of mammalian sterol biosynthesis that converts 7-dehydrocholesterol (7-DHC) to cholesterol. This enzyme removes the C(7–8) double bond introduced by the sterol delta8-delta7 isomerases. In addition, its role in drug-induced malformations is known: inhibitors of the last step of cholesterol biosynthesis such as AY9944 and BM15766 severely impair brain development.[5]
It displays a modest level of enzyme promiscuity, being able to catalyze analogous reactions with (substrate in forward direction) brassicasterol,[9] 20S(OH)7DHC, 27(OH)DHC and 7-dehydrodesmosterol.[10]
Pathology
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
- The interactive pathway map can be edited at WikiPathways: "VitaminDSynthesis_WP1531".
