7-Methylguanine

7-Methylguanine is a modified purine nucleobase. It is a methylated version of guanine. The 7-methylguanine nucleoside is called 7-methylguanosine. However, the free 7-methylguanine base is not involved in the synthesis of nucleotides and not incorporated directly into nucleic acids.^[1][2] 7-Methylguanine is a natural inhibitor of poly (ADP-ribose) polymerase (PARP) and tRNA guanine transglycosylase (TGT) - and thus may exert anticancer activity.^[3][4][5] For example, it was demonstrated that 7-methylguanine could accelerate apoptotic death of BRCA1-deficient breast cancer cells induced by cisplatin and doxorubicin.^[6]

Quick facts Names, Identifiers ...

7-Methylguanine

Names
IUPAC name 7-Methylguanine
Preferred IUPAC name 2-Amino-7-methyl-1,7-dihydro-6H-purin-6-one
Other names N7-Methylguanine; Epiguanine
Identifiers
CAS Number	578-76-7 Y[Pubchem]
3D model (JSmol)	Interactive image
Beilstein Reference	174245
ChEBI	CHEBI:2274 Y
ChemSpider	10883 Y
ECHA InfoCard	100.008.575
EC Number	209-431-0
KEGG	C02242
PubChem CID	135398679
UNII	661J4K04NB
CompTox Dashboard (EPA)	DTXSID9020873
InChI InChI=1S/C6H7N5O/c1-11-2-8-4-3(11)5(12)10-6(7)9-4/h2H,1H3,(H3,7,9,10,12) Key: FZWGECJQACGGTI-UHFFFAOYSA-N
SMILES CN1C=NC2=C1C(=O)N=C(N2)N
Properties
Chemical formula	C6H7N5O
Molar mass	165.156 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

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