Α-Pyrrolidinohexiophenone
Stimulant drug
From Wikipedia, the free encyclopedia
α-Pyrrolidinohexiophenone (α-PHP, A-PHP, Aphp, alpha-PHP, α-Pyrrolidinohexanophenone, PV-7) is a synthetic stimulant drug of the cathinone class developed in the 1960s[2] which has been reported as a novel designer drug.[3][4][5][6][7]
administrationOral, intranasal, vaporization, intravenous, rectal, sublingual, subcutaneous
- BR: Class F2 (Prohibited psychotropics)[1]
- DE: Anlage II (Authorized trade only, not prescriptible)
- UK: Class B
- US: Schedule I
- UN: Psychotropic Schedule II
- Illegal in China, Sweden and Italy
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| Routes of administration | Oral, intranasal, vaporization, intravenous, rectal, sublingual, subcutaneous |
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| Formula | C16H23NO |
| Molar mass | 245.366 g·mol−1 |
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Similar chemical compounds
α-Pyrrolidinohexiophenone is a longer chain homologue of α-PVP, having an extra carbon on the alkyl side chain. Regarding the potency of alpha-PHP in the brain, chemist Michael H. Baumann of the Designer Drug Research Unit (established by Baumann[8]) of the National Institute on Drug Abuse stated: "alpha-PHP might be even more potent than alpha-PVP"; this statement is based on laboratory tests of chemical reactivity.[9]
Pyrovalerone is a structural isomer of alpha-PHP.[10]
Pharmacology
| Drug | NET | DAT | SERT | DAT/SERT Ratio |
|---|---|---|---|---|
| ⍺-PVP | 0.02 (0.01‒0.05) | 0.03 (0.02‒0.04) | 279 (209‒372) | >1000 |
| ⍺-PHP | 0.06 (0.03‒0.12) | 0.06 (0.05‒0.08) | 245 (173‒348) | >1000 |
| MDMA | 0.41 (0.33‒0.52) | 13 (11‒16) | 1.6 (1.2‒2.2) | 0.12 (0.08‒0.20) |
| Amphetamine | 0.07 (0.05‒0.1) | 1.3 (0.8‒2.0) | 45 (24‒85) | 35 (12‒106) |
Legality
The President of the Republic of Italy classified cathinone and all structurally derived analogues (including pyrovalerone analogues) as narcotics in January 2012.[12][13]
Sweden's public health agency suggested to classify α-PHP as narcotic on June 1, 2015.[14]
As of October 2015, α-PHP is a controlled substance in China.[15]
In December 2019, the UNODC announced scheduling recommendations placing Alpha-PHP into Schedule II.[16]
As of 29 October 2021, α-PHP has been banned in the Netherlands under the 1971 Vienna Convention on Psychotropic Substances.[17]
In the US, a-PHP is a Schedule I controlled substance as of 2022.[18]