AH receptor-interacting protein
Protein found in humans
From Wikipedia, the free encyclopedia
AH receptor-interacting protein (AIP) also known as aryl hydrocarbon receptor-interacting protein, immunophilin homolog ARA9, or HBV X-associated protein 2 (XAP-2) is a protein that in humans is encoded by the AIP gene.[5][6][7] The protein is a member of the FKBP family.
| AIP | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | AIP, ARA9, FKBP16, FKBP37, SMTPHN, XAP-2, XAP2, aryl hydrocarbon receptor interacting protein, PITA1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605555; MGI: 109622; HomoloGene: 2959; GeneCards: AIP; OMA:AIP - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
AIP may play a positive role in aryl hydrocarbon receptor-mediated signalling possibly by influencing its receptivity for ligand and/or its nuclear targeting. AIP is the cellular negative regulator of the hepatitis B virus (HBV) X protein.[5] Further, it's been known to suppress antiviral signaling and the induction of type I interferon by targeting IRF7, a key player in the antiviral signal pathways.[8] AIP consists of an N-terminal FKBP52 like domain and a C-terminal TPR domain.[9]
Mutations and role in disease
AIP mutations may be the cause of a familial form of acromegaly, familial isolated pituitary adenoma (FIPA). Somatotropinomas (i.e. GH-producing pituitary adenomas), sometimes associated with prolactinomas, are present in most AIP mutated patients.[10]
Interactions
AIP has been shown to interact with the aryl hydrocarbon receptor,[7][11][12] peroxisome proliferator-activated receptor alpha[13] and the aryl hydrocarbon receptor nuclear translocator.[7][14] Further, it has shown that AIP can interact with IRF7 to exert its novel function of negatively regulating antiviral signal pathways.[8]