Turletricin

Turletricin
Legal status
Legal status	In general: unscheduled;
Identifiers
CAS Number	2761794-74-3;
PubChem CID	170453316;
Chemical and physical data
3D model (JSmol)	Interactive image;
	SMILES [C@H]1[C@H](C)OC(C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O2)(O)C[C@H](O)[C@@H](C(NC(CO)CO)=O)[C@@H]2C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@H]3O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@H]1O)=O;
	InChI InChI=1S/C50H80N2O18/c1-29-17-15-13-11-9-7-5-6-8-10-12-14-16-18-37(69-49-47(64)44(51)46(63)32(4)68-49)24-41-43(48(65)52-33(27-53)28-54)40(60)26-50(66,70-41)25-36(57)22-39(59)38(58)20-19-34(55)21-35(56)23-42(61)67-31(3)30(2)45(29)62/h5-18,29-41,43-47,49,53-60,62-64,66H,19-28,51H2,1-4H3,(H,52,65)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t29-,30-,31-,32+,34+,35+,36-,37-,38+,39+,40-,41-,43+,44-,45+,46+,47+,49-,50+/m0/s1; Key:DYFDQVUOYRWTOB-JYUTVPRCSA-N;

Turletricin (also known as AM-2-19 and SF001) is an experimental antifungal drug based on amphotericin B (AmB) that is engineered to be less toxic to the kidneys.^[1]^[2]^[3]

Legal status

In general: unscheduled

CAS Number

2761794-74-3

PubChem CID

170453316

3D model (JSmol)

Interactive image

Quick facts Legal status, Identifiers ...

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Amphotericin B is a polyene that targets fungal ergosterol as well as human cholesterol, which results in kidney damage. Turletricin instead is selective to fungal ergosterol and also draws out fungal ergosterol more effectively. The investigational new drug (IND) application was filed in May 2023. Turletricin received Qualified Infectious Disease Product (QIDP) for invasive aspergillosis and Fast Track designations from the FDA in 2023. It is now under phase II trial.

An oral formulation is currently in the feasibility phase.

[1]

[2]

[3]

Turletricin

References

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