Annexin A3

Annexin A3 is a protein that in humans is encoded by the ANXA3 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesANXA3, ANX3, annexin A3

External IDsOMIM: 106490; MGI: 1201378; HomoloGene: 68445; GeneCards: ANXA3; OMA:ANXA3 - orthologs

Chr.Chromosome 4 (human)^[1]

Quick facts ANXA3, Available structures ...

ANXA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AII, 1AXN
Identifiers
Aliases	ANXA3, ANX3, annexin A3
External IDs	OMIM: 106490; MGI: 1201378; HomoloGene: 68445; GeneCards: ANXA3; OMA:ANXA3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.21 Start 78,551,747 bp[1] End 78,610,451 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 E3|5 47.29 cM Start 96,941,198 bp[2] End 96,993,825 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung germinal epithelium bone marrow upper lobe of left lung bone marrow cell minor salivary glands left lobe of thyroid gland trabecular bone right lobe of thyroid gland body of stomach Top expressed in right lung lobe mucous cell of stomach pyloric antrum endothelial cell of lymphatic vessel left lung granulocyte left lung lobe decidua epithelium of stomach gastrula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phospholipase inhibitor activity calcium ion binding phospholipase A2 inhibitor activity calcium-dependent protein binding calcium-dependent phospholipid binding Cellular component cytoplasm phagocytic vesicle membrane membrane plasma membrane axon soma dendrite specific granule extracellular exosome cytosol Biological process negative regulation of catalytic activity positive regulation of DNA metabolic process neutrophil degranulation positive regulation of DNA-binding transcription factor activity response to glucocorticoid positive regulation of angiogenesis positive regulation of endothelial cell migration defense response to bacterium animal organ regeneration phagocytosis response to growth factor hippocampus development homophilic cell adhesion via plasma membrane adhesion molecules regulation of NMDA receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 306 11745 Ensembl ENSG00000138772 ENSMUSG00000029484 UniProt P12429 O35639 RefSeq (mRNA) NM_005139 NM_013470 RefSeq (protein) NP_005130 NP_038498 Location (UCSC) Chr 4: 78.55 – 78.61 Mb Chr 5: 96.94 – 96.99 Mb PubMed search [3] [4]
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It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART.^[7]

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.^[6]