Apolipoprotein C-II

Apolipoprotein C-II (Apo-CII, or Apoc-II), or apolipoprotein C2 is a protein that in humans is encoded by the APOC2 gene.

PDBOrtholog search: PDBe RCSB

AliasesAPOC2, APO-CII, APOC-II, apolipoprotein C2

External IDsOMIM: 608083; MGI: 88054; HomoloGene: 47928; GeneCards: APOC2; OMA:APOC2 - orthologs

Chr.Chromosome 19 (human)^[1]

Quick facts APOC2, Available structures ...

APOC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SOH, 1BY6, 1I5J, 1O8T
Identifiers
Aliases	APOC2, APO-CII, APOC-II, apolipoprotein C2
External IDs	OMIM: 608083; MGI: 88054; HomoloGene: 47928; GeneCards: APOC2; OMA:APOC2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 44,946,035 bp[1] End 44,949,565 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 9.94 cM Start 19,405,504 bp[2] End 19,411,866 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver substantia nigra C1 segment duodenum caudate nucleus putamen amygdala testicle nucleus accumbens hypothalamus Top expressed in yolk sac duodenum liver jejunum ileum spermatocyte colon granulocyte pulmonary alveolus wall of pulmonary alveolus More reference expression data BioGPS n/a
Gene ontology Molecular function lipase inhibitor activity phospholipase binding protein homodimerization activity lipoprotein lipase activator activity phospholipase activator activity enzyme activator activity lipid binding Cellular component chylomicron very-low-density lipoprotein particle spherical high-density lipoprotein particle extracellular region early endosome low-density lipoprotein particle high-density lipoprotein particle intermediate-density lipoprotein particle extracellular space Biological process high-density lipoprotein particle clearance lipid transport positive regulation of triglyceride catabolic process chylomicron remnant clearance lipid metabolism phospholipid efflux positive regulation of lipoprotein lipase activity positive regulation of fatty acid biosynthetic process negative regulation of very-low-density lipoprotein particle clearance retinoid metabolic process negative regulation of receptor-mediated endocytosis lipid catabolic process positive regulation of phospholipase activity positive regulation of phospholipid catabolic process cholesterol efflux very-low-density lipoprotein particle remodeling negative regulation of cholesterol transport cholesterol homeostasis positive regulation of very-low-density lipoprotein particle remodeling triglyceride-rich lipoprotein particle remodeling triglyceride homeostasis negative regulation of lipid metabolic process reverse cholesterol transport negative regulation of catalytic activity lipoprotein transport chylomicron remodeling high-density lipoprotein particle remodeling chylomicron assembly positive regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 344 11813 Ensembl ENSG00000234906 ENSMUSG00000002992 UniProt P02655 Q05020 RefSeq (mRNA) NM_000483 NM_001277944 NM_001309795 RefSeq (protein) NP_000474 NP_000474.2 NP_001296728 NP_001264873 NP_001296724 Location (UCSC) Chr 19: 44.95 – 44.95 Mb Chr 7: 19.41 – 19.41 Mb PubMed search [3] [4]
Wikidata
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SymbolApo-CII

PfamPF05355

InterProIPR008019

SCOP21by6 / SCOPe / SUPFAM

Quick facts Apo-CII, Identifiers ...

Apo-CII
nmr structure of human apolipoprotein c-ii in the presence of sds
Identifiers
Symbol	Apo-CII
Pfam	PF05355
InterPro	IPR008019
SCOP2	1by6 / SCOPe / SUPFAM
Available protein structures: PDB   IPR008019 PF05355 (ECOD; PDBsum)   AlphaFold IPR008019 PF05355

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The protein encoded by this gene is secreted in plasma, where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries,^[5] which hydrolyzes triglycerides and thus provides free fatty acids and glycerols for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by xanthomas, pancreatitis, and hepatosplenomegaly, but no increased risk for atherosclerosis. Lab tests will show elevated blood levels of triglycerides, cholesterol, and chylomicrons^[6]