ATOH8

ATOH8
Identifiers
Aliases	ATOH8, HATH6, bHLHa21, atonal bHLH transcription factor 8
External IDs	MGI: 1918343; GeneCards: ATOH8
Gene location (Human)
Chr.	Chromosome 2 (human)
End	85,791,383 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	72,212,561 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; right lung; ; tibial nerve; ; popliteal artery; ; tibial arteries; ; thoracic aorta; ; right auricle of heart; ; ascending aorta; ; apex of heart;
	Top expressed in
	spermatid; ; gastrula; ; seminiferous tubule; ; spermatocyte; ; tail of embryo; ; genital tubercle; ; endothelial cell of lymphatic vessel; ; aortic valve; ; muscle of thigh; ; ascending aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein dimerization activity; DNA-binding transcription factor activity; transcription factor binding; E-box binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nuclear speck; nucleus; nucleoplasm;
Biological process	cell differentiation; positive regulation of endothelial cell differentiation; regulation of transcription, DNA-templated; SMAD protein signal transduction; transcription, DNA-templated; nervous system development; negative regulation of endothelial cell proliferation; positive regulation of endothelial cell migration; positive regulation of transcription, DNA-templated; multicellular organism development; tube formation; myoblast proliferation; formation of primary germ layer; negative regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; positive regulation of gene expression; negative regulation of gene expression; positive regulation of pri-miRNA transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	84913
	71093
	ENSG00000168874
	ENSMUSG00000037621
	Q96SQ7
	Q99NA2
	NM_032827
	NM_153778
	NP_116216
	NP_722473
	Wikidata
View/Edit Human	View/Edit Mouse

Atonal bHLH transcription factor 8 is a protein that in humans is encoded by the ATOH8 gene.^[5] It is hypothesized to play a role endochondral ossification as a regulator of chondrocyte proliferation and differentiation.^[6] In addition, it also participates in the chondrogenesis of limb bud mesenchymal progenitor cells.^[7]