Acetate—CoA ligase (ADP-forming)
Class of enzymes
From Wikipedia, the free encyclopedia
In enzymology, an acetate—CoA ligase (ADP-forming) (EC 6.2.1.13) is an enzyme that catalyzes the chemical reaction
- ATP + acetate + CoA ADP + phosphate + acetyl-CoA
| Acetate—CoA ligase (ADP-forming) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Acyl-CoA synthetase (NDP forming) heterotetramer, Candidatus Korarchaeum | |||||||||
| Identifiers | |||||||||
| EC no. | 6.2.1.13 | ||||||||
| CAS no. | 62009-85-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are ATP, acetate, and CoA, whereas its 3 products are ADP, phosphate, and acetyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acetate:CoA ligase (ADP-forming). Other names in common use include acetyl-CoA synthetase (ADP-forming), acetyl coenzyme A synthetase (adenosine diphosphate-forming), and acetate thiokinase. This enzyme participates in pyruvate metabolism and propanoate metabolism.
References
- Reeves RE, Warren LG, Susskind B, Lo HS (1977). "An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase". J. Biol. Chem. 252 (2): 726–31. doi:10.1016/S0021-9258(17)32778-3. PMID 13076.
