Application site reaction
Medical condition
From Wikipedia, the free encyclopedia
Application site reactions are reactions to medical treatments which occur at the site of application. An example is skin reactions to transdermal patches.[1]
| Application site reaction | |
|---|---|
| |
| 52-year-old male patient with severe contact dermatitis and severe pain at the application site of a 15mcg/hr buprenorphine transdermal (Norspan) patch. | |
| Specialty | Dermatology |
These reactions may be caused by:
- Irritant (non-allergic) reactions — the most common type, caused by direct skin irritation from adhesives, solvents, or the drug itself.[2].
- Allergic reactions — usually allergic contact dermatitis, a delayed hypersensitivity immune response to an allergen such as patch adhesive, excipients, or the active drug.[3]
- Mechanical forces
Some application site reactions are neither allergic nor irritant in immunologic terms, but result from friction, occlusion, pressure, or repeated removal trauma.[4]
- Local inflammatory injection unrelated to allergy
Implants may trigger localized redness, swelling, pain, or induration due to nonspecific inflammation rather than allergy.[4]
