Alpha/beta hydrolase superfamily
Protein family
From Wikipedia, the free encyclopedia
The alpha/beta hydrolase superfamily is a superfamily of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function that share a common fold.[1] The core of each enzyme is an alpha/beta-sheet (rather than a barrel), containing 8 beta strands connected by 6 alpha helices.[1][2] The enzymes are believed to have diverged from a common ancestor, retaining little obvious sequence similarity, but preserving the arrangement of the catalytic residues. All have a catalytic triad, the elements of which are borne on loops, which are the best-conserved structural features of the fold.
The alpha/beta hydrolase fold includes proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases.[3]
Database
The ESTHER database provides a large collection of information about this superfamily of proteins.[4]
Subfamilies
Human proteins containing this domain
See also
- Ecdysteroid-phosphate phosphatase - structure of a steroid phosphate phosphotase
- Serine hydrolase - an enzyme family that is composed largely of proteins with alpha-beta hydrolase folds
