Motexafin lutetium

Chemical compound From Wikipedia, the free encyclopedia

Motexafin lutetium is a texaphyrin, marketed as Antrin by Pharmacyclics Inc.

Quick facts Names, Identifiers ...
Motexafin lutetium
Names
Other names
Antrin; Lu texaphyrin; Lu-Tex; Lutetium texaphyrin; Lutrin; Optrin; PCI 0123
Identifiers
3D model (JSmol)
ChemSpider
DrugBank
UNII
  • InChI=1S/C48H66N5O10.2C2H4O2.Lu.H2O/c1-7-35-36(8-2)40-28-42-38(12-10-14-55)34(4)46(53-42)32-50-44-30-48(63-26-24-61-22-20-59-18-16-57-6)47(62-25-23-60-21-19-58-17-15-56-5)29-43(44)49-31-45-33(3)37(11-9-13-54)41(52-45)27-39(35)51-40;2*1-2(3)4;;/h27-32,54-55H,7-26H2,1-6H3;2*1H3,(H,3,4);;1H2/q-1;;;+3;/p-2
    Key: WIQKYZYFTAEWBF-UHFFFAOYSA-L
  • CC([O-])=O.CCC1=C2[N-]C(/C=C3N=C(/C=N/C4=CC(OCCOCCOCCOC)=C(OCCOCCOCCOC)C=C4/N=C/C(C(C)=C/5CCCO)=[N]([Lu+3])C5=C/2)C(C)=C\3CCCO)=C1CC
Properties
C52H72LuN5O14
Molar mass 1166.136 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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It is a photosensitiser for use in photodynamic therapy to treat skin conditions and superficial cancers.

It has also been tested for use in photoangioplasty (photodynamic treatment of diseased arteries).[1]

It is photoactivated by 732 nm light which allows greater depth of penetration.[2]

Clinical trials

Phase II clinical trials were in progress in 1999.[3]

A phase I trial for prostate cancer reported in 2009.[4]

References

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