Asoxime chloride
Chemical compound
From Wikipedia, the free encyclopedia
Asoxime chloride, or more commonly HI-6, is a Hagedorn oxime used in the treatment of organophosphate poisoning.[1]
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- Experimental
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| Routes of administration | Intramuscular injection |
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| Formula | C14H16Cl2N4O3 |
| Molar mass | 359.21 g·mol−1 |
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Discovery
HI-6 was developed in the 1968 in Ilse Hagedorn[2]'s lab at the University of Freiburg in then West Germany as a potent antidote for poisoning by organophosphorus nerve agents.[3] The compound was created in response to limitations of earlier oxime antidotes, which were effective against some nerve agents but failed to protect against others such as soman.[4]
Structure
Much line pralidoxime, asoxime and other oximes created in the Hagedorn lab (i.e. LüH-6, HLö-7) are pyridine oximes, sharing the same structural feature of a byspyridinium nucleus. Position 2 and 4 on one of the pyridine rings is essential for pharmacological activity, as is position 4 on the second ring for both efficacy and toxic effects alike. Amidation on the second ring at position 4 is essential for reducing toxicity of the derivative compounds[5].
