Brain-specific angiogenesis inhibitor 2

ADGRB2
Identifiers
Aliases	ADGRB2, BAI2, adhesion G protein-coupled receptor B2
External IDs	OMIM: 602683; MGI: 2451244; HomoloGene: 1288; GeneCards: ADGRB2; OMA:ADGRB2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	31,764,893 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	129,916,426 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; prefrontal cortex; ; anterior cingulate cortex; ; ganglionic eminence; ; dorsolateral prefrontal cortex; ; nucleus accumbens; ; caudate nucleus; ; Brodmann area 9; ; Brodmann area 10; ; amygdala;
	Top expressed in
	primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; subiculum; ; hippocampus proper; ; prefrontal cortex; ; piriform cortex; ; olfactory tubercle; ; primary motor cortex; ; cingulate gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane signaling receptor activity; signal transducer activity; G protein-coupled receptor activity; protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane; centrosome; integral component of plasma membrane;
Biological process	negative regulation of angiogenesis; cell surface receptor signaling pathway; peripheral nervous system development; signal transduction; positive regulation of synapse assembly; G protein-coupled receptor signaling pathway; calcineurin-NFAT signaling cascade; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	576
	230775
	ENSG00000121753
	ENSMUSG00000028782
	O60241
	Q8CGM1
	NM_001294335; NM_001294336; NM_001364857
NM_001199696; NM_001290714; NM_001290715; NM_173071; NM_001377056;
	NM_001377057; NM_001377058
	NP_001281264; NP_001281265; NP_001351786
NP_001186625; NP_001277643; NP_001277644; NP_775094; NP_001363985;
	NP_001363986; NP_001363987
	Wikidata
View/Edit Human	View/Edit Mouse

Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene.^[5]^[6] It is a member of the adhesion-GPCR family of receptors.^[7]

AliasesADGRB2, BAI2, adhesion G protein-coupled receptor B2

External IDsOMIM: 602683; MGI: 2451244; HomoloGene: 1288; GeneCards: ADGRB2; OMA:ADGRB2 - orthologs

Chr.Chromosome 1 (human)^[1]

End31,764,893 bp^[1]

Quick facts ADGRB2, Identifiers ...

Close

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.^[6]

[5]

[6]

[7]

[1]

[2]

[3]

[4]

Brain-specific angiogenesis inhibitor 2

References

Further reading

External links

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