Brain-specific angiogenesis inhibitor 3

Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesADGRB3, BAI3, adhesion G protein-coupled receptor B3

External IDsOMIM: 602684; MGI: 2441837; HomoloGene: 1289; GeneCards: ADGRB3; OMA:ADGRB3 - orthologs

Chr.Chromosome 6 (human)^[1]

Quick facts ADGRB3, Available structures ...

ADGRB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DLO
Identifiers
Aliases	ADGRB3, BAI3, adhesion G protein-coupled receptor B3
External IDs	OMIM: 602684; MGI: 2441837; HomoloGene: 1289; GeneCards: ADGRB3; OMA:ADGRB3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q12-q13 Start 68,635,282 bp[1] End 69,390,571 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A5 Start 25,106,557 bp[2] End 25,868,788 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus endothelial cell Brodmann area 23 ventricular zone orbitofrontal cortex superior frontal gyrus Brodmann area 46 postcentral gyrus entorhinal cortex Region I of hippocampus proper Top expressed in lateral septal nucleus nucleus accumbens anterior amygdaloid area olfactory tubercle ventromedial nucleus lobe of cerebellum cerebellar vermis medial geniculate nucleus subiculum Region I of hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity protein binding transmembrane signaling receptor activity signal transducer activity GTPase activator activity Cellular component integral component of membrane plasma membrane membrane postsynapse synaptic cleft intracellular anatomical structure integral component of plasma membrane Biological process negative regulation of angiogenesis G protein-coupled receptor signaling pathway positive regulation of GTPase activity cell surface receptor signaling pathway myoblast fusion signal transduction positive regulation of synapse assembly regulation of dendrite morphogenesis motor learning maintenance of synapse structure neuron remodeling adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 577 210933 Ensembl ENSG00000135298 ENSMUSG00000033569 UniProt O60242 Q80ZF8 RefSeq (mRNA) NM_001704 NM_175642 RefSeq (protein) NP_001695 NP_783573 Location (UCSC) Chr 6: 68.64 – 69.39 Mb Chr 1: 25.11 – 25.87 Mb PubMed search [3] [4]
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BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.^[6] The BAI3 receptor has also been found to regulate dendrite morphogenesis, arborization growth and branching in cultured neurons.^[7]

The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.^[8] BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.