Bcl-2-like protein 1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Bcl-2-like protein 1 is a protein encoded in humans by the BCL2L1 gene. Through alternative splicing, the gene encodes both of the human proteins Bcl-xL and Bcl-xS.[5]
Function
The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (voltage-dependent anion channels (VDACs) opening. VDACs regulate mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform (Bcl-xL) acts as an apoptotic inhibitor and the shorter form (Bcl-xS) acts as an apoptotic activator.[5][6]
Interactions
BCL2-like 1 (gene) has been shown to interact with:
- APAF1,[7][8]
- BAK1,[9][10][11][12][13]
- BCAP31,[14]
- BCL2L11,[11][15][16][17]
- BNIP3,[18]
- BNIPL,[19][20]
- BAD,[10][15][21][22][23][24][25][26][27][28][29]
- BAX,[10][22][30][31]
- BIK,[9][15][31][32]
- Bcl-2,[10][33]
- HRK,[11][34][35]
- IKZF3,[36]
- Noxa,[15][37]
- PPP1CA,[23]
- PSEN2[38]
- RAD9A,[9][21]
- RTN1,[39]
- RTN4,[39] and
- VDAC1.[40][41][42][43]