Baeyer–Drewsen indigo synthesis
Organic reaction in which indigo is prepared from 2-nitrobenzaldehyde and acetone
From Wikipedia, the free encyclopedia
The Baeyer–Drewsen indigo synthesis (1882) is an organic reaction in which indigo is prepared from 2-nitrobenzaldehyde and acetone[1][2] The reaction was developed by von Baeyer and Viggo Drewsen in 1880 to produce the first synthetic indigo at laboratory scale. This procedure is not used at industrial scale.[3]
The reaction is classified as an aldol condensation. As a practical route to indigo, this method was displaced by routes from aniline.[4]
Mechanism
Note
In the English literature this reaction is sometimes called Baeyer–Drewson reaction, although the author of the original paper was spelled Drewsen.