Tretinoin/benzoyl peroxide
Medication for Acne
From Wikipedia, the free encyclopedia
Tretinoin/benzoyl peroxide, sold under the brand name Twyneo, is a fixed-dose combination medication used for the treatment of acne.[1][2] It contains tretinoin, a vitamin A derivative, and benzoyl peroxide, an oxidizing agent.[3]
| Combination of | |
|---|---|
| Tretinoin | Retinoid |
| Benzoyl peroxide | Oxidizing agent |
| Clinical data | |
| Trade names | Twyneo |
| Other names | S6G5T-3 |
| License data | |
| Routes of administration | Topical |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| KEGG | |
The U.S. Food and Drug Administration (FDA) approved this medication for use in July 2021.[2][4][5] Historically, the co-formulation of these two active ingredients was avoided because benzoyl peroxide typically causes the oxidative degradation of tretinoin when stored together.[6] To address this stability issue, Twyneo employs a silica-based sol-gel microencapsulation technology, which serves as a physical barrier that prevents the benzoyl peroxide from damaging the tretinoin within the vehicle.[7]
