Nobiletin
Chemical compound
From Wikipedia, the free encyclopedia
Nobiletin is a flavonoid isolated from citrus peels. It is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.[1]
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| Names | |
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| IUPAC name
3′,4′,5,6,7,8-Hexamethoxyflavone | |
| Systematic IUPAC name
2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one | |
| Other names
Hexamethoxyflavone | |
| Identifiers | |
3D model (JSmol) |
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PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C21H22O8 | |
| Molar mass | 402.399 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Potential pharmacology
Nobiletin was found to potentially inhibit cartilage degradation.[2]
Nobiletin was shown to augment AMPA receptor activity and long-term potentiation in cell culture.[3] Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis have been described.[4] Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer[5].
