Centhaquine

Centhaquine
Clinical data
Trade names	Lyfaquin
Other names	Centhaquin; PMZ-2010; Compound-7173
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 2-[2-[4-(3-Methylphenyl)piperazin-1-yl]ethyl]quinoline;
CAS Number	57961-90-7;
PubChem CID	162163;
DrugBank	DB16122;
ChemSpider	142413;
UNII	QD4VI0J9T5;
KEGG	D11974;
ChEMBL	ChEMBL4594437;
CompTox Dashboard (EPA)	DTXSID40206680 ;
Chemical and physical data
Formula	C22H25N3
Molar mass	331.463 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC(=CC=C1)N2CCN(CC2)CCC3=NC4=CC=CC=C4C=C3;
	InChI InChI=1S/C22H25N3/c1-18-5-4-7-21(17-18)25-15-13-24(14-16-25)12-11-20-10-9-19-6-2-3-8-22(19)23-20/h2-10,17H,11-16H2,1H3; Key:UJNWGFBJUHIJKK-UHFFFAOYSA-N;

Centhaquine (brand name Lyfaquin) is a cardiovascular drug.^[1] In India, it is approved for the treatment of hypovolemic shock.^[2]

Other namesCenthaquin; PMZ-2010; Compound-7173

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Centhaquine is a vasopressor that activates α_2A- and α_2B-adrenoreceptors.^[3] It increases venous return and improves tissue perfusion. The drug has more recently been identified as a potent and selective serotonin 5-HT_2C receptor agonist (EC₅₀Tooltip half-maximal effective concentration = 35 nM).^[4] It has no detectable activity at the serotonin 5-HT_2B or 5-HT_2C receptors.^[4]

References