LY-2365109

LY-2365109 is a glycine reuptake inhibitor. It is able to inhibit the type 1 glycine transporter.^[1] This inhibition increases extracellular levels of glycine. LY-2365109 has been shown to increase the seizure threshold in mice, meaning that this drug has potential as an anticonvulsant.^[2]

Quick facts Names, Identifiers ...

LY-2365109

Names
IUPAC name 2-[2-[4-(1,3-Benzodioxol-5-yl)-2-tert-butylphenoxy]ethyl-methylamino]acetic acid
Identifiers
CAS Number	hydrochoride: 868265-28-5
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL1628564
ChemSpider	9727535
PubChem CID	11552757
InChI InChI=1S/C22H27NO5/c1-22(2,3)17-11-15(16-6-8-19-20(12-16)28-14-27-19)5-7-18(17)26-10-9-23(4)13-21(24)25/h5-8,11-12H,9-10,13-14H2,1-4H3,(H,24,25) Key: FKPLJWGRBCQLTL-UHFFFAOYSA-N
SMILES CC(C)(C)C1=C(C=CC(=C1)C2=CC3=C(C=C2)OCO3)OCCN(C)CC(=O)O
Properties
Chemical formula	C22H27NO5
Molar mass	385.460 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

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