Oxalosuccinic acid

Oxalosuccinic acid is a substrate of the citric acid cycle. It is acted upon by isocitrate dehydrogenase. Salts and esters of oxalosuccinic acid are known as oxalosuccinates.

Quick facts Names, Identifiers ...

Oxalosuccinic acid

Names
Preferred IUPAC name 1-Oxopropane-1,2,3-tricarboxylic acid
Identifiers
CAS Number	1948-82-9 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:7815 N
ChemSpider	947 N
ECHA InfoCard	100.230.021
KEGG	C05379 N
PubChem CID	972
UNII	DFK99PW32K Y
CompTox Dashboard (EPA)	DTXSID30862799
InChI InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13) N Key: UFSCUAXLTRFIDC-UHFFFAOYSA-N N InChI=1/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13) Key: UFSCUAXLTRFIDC-UHFFFAOYAK
SMILES C(C(C(=O)C(=O)O)C(=O)O)C(=O)O
Properties
Chemical formula	C6H6O7
Molar mass	190.108
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

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Oxalosuccinic acid/oxalosuccinate is an unstable 6-carbon intermediate in the tricarboxylic acid cycle. It's a keto acid, formed during the oxidative decarboxylation of isocitrate to alpha-ketoglutarate, which is catalyzed by the enzyme isocitrate dehydrogenase. Isocitrate is first oxidized by coenzyme NAD+ to form oxalosuccinic acid/oxalosuccinate.^[1] Oxalosuccinic acid is both an alpha-keto and a beta-keto acid (an unstable compound) and it is the beta-ketoic property that allows the loss of carbon dioxide in the enzymatic reaction in conversion to the five-carbon molecule 2-oxoglutarate.^[2]