CAMK4

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.^[5]

AliasesCAMK4, CaMK IV, CaMK-GR, IV, caMK, calcium/calmodulin-dependent protein kinase IV, calcium/calmodulin dependent protein kinase IV, CaMKIV

External IDsOMIM: 114080; MGI: 88258; GeneCards: CAMK4

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 5 (human)^[1]

Quick facts Identifiers, Aliases ...

CAMK4
Identifiers
Aliases	CAMK4, CaMK IV, CaMK-GR, IV, caMK, calcium/calmodulin-dependent protein kinase IV, calcium/calmodulin dependent protein kinase IV, CaMKIV
External IDs	OMIM: 114080; MGI: 88258; GeneCards: CAMK4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2W4O
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.7.11.17 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q22.1 Start 111,223,653 bp[1] End 111,494,886 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B1|18 18.15 cM Start 33,067,984 bp[2] End 33,324,281 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis cerebellar hemisphere right hemisphere of cerebellum middle temporal gyrus left testis right testis paraflocculus of cerebellum ganglionic eminence nucleus accumbens superior frontal gyrus Top expressed in cerebellar cortex superior frontal gyrus thymus primary visual cortex lobe of cerebellum seminiferous tubule dentate gyrus of hippocampal formation granule cell cerebellar vermis spermatid olfactory tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity calcium-dependent protein serine/threonine kinase activity calmodulin binding kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity ATP binding Cellular component cytoplasm cytosol nucleoplasm extracellular exosome nucleus fibrillar center postsynapse glutamatergic synapse Biological process intracellular signal transduction adaptive immune response myeloid dendritic cell cytokine production phosphorylation immune system process myeloid dendritic cell differentiation positive regulation of transcription, DNA-templated regulation of T cell differentiation in thymus protein phosphorylation regulation of osteoclast differentiation long-term memory peptidyl-serine phosphorylation protein autophosphorylation inflammatory response signal transduction Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 814 12326 Ensembl ENSG00000152495 ENSMUSG00000038128 UniProt Q16566 P08414 Q8BGR3 RefSeq (mRNA) NM_001744 NM_001323374 NM_001323375 NM_001323376 NM_001323377 NM_009793 RefSeq (protein) NP_001310303 NP_001310304 NP_001310305 NP_001310306 NP_001735 NP_033923 Location (UCSC) Chr 5: 111.22 – 111.49 Mb Chr 18: 33.07 – 33.32 Mb PubMed search [3] [4]
Wikidata
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The product of this gene belongs to the serine/threonine protein kinase cluster, and to the Ca²⁺/calmodulin-dependent protein kinase (CAMK) group. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells.^[6]