Capping protein (actin filament) muscle Z-line, alpha 1

Protein found in humans From Wikipedia, the free encyclopedia

F-actin-capping protein subunit alpha-1 is a protein that in humans is encoded by the CAPZA1 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesCAPZA1, CAPPA1, CAPZ, CAZ1, capping actin protein of muscle Z-line alpha subunit 1, capping actin protein of muscle Z-line subunit alpha 1
Quick facts CAPZA1, Available structures ...
CAPZA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAPZA1, CAPPA1, CAPZ, CAZ1, capping actin protein of muscle Z-line alpha subunit 1, capping actin protein of muscle Z-line subunit alpha 1
External IDsOMIM: 601580; MGI: 106227; HomoloGene: 24376; GeneCards: CAPZA1; OMA:CAPZA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006135

NM_009797
NM_001355044

RefSeq (protein)

NP_006126

NP_033927
NP_001341973

Location (UCSC)Chr 1: 112.62 – 112.67 MbChr 3: 104.73 – 104.77 Mb
PubMed search[3][4]
Wikidata
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CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein.

Function

The protein regulates growth of the actin filament by capping the barbed end (plus-end) of growing actin filaments, preventing any further assembly from occurring.[7] This protein can be bound to the lipid PIP2 preventing it from binding to actin filaments.

References

Further reading

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