SIRPG

Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene.^[5][6][7] SIRPG has also recently been designated CD172G (cluster of differentiation 172G).

AliasesSIRPG, CD172g, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1, signal regulatory protein gamma

External IDsOMIM: 605466; MGI: 108563; GeneCards: SIRPG

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 20 (human)^[1]

Quick facts Identifiers, Aliases ...

SIRPG
Identifiers
Aliases	SIRPG, CD172g, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1, signal regulatory protein gamma
External IDs	OMIM: 605466; MGI: 108563; GeneCards: SIRPG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JJW, 4I2X
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 1,629,152 bp[1] End 1,657,779 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 63.19 cM Start 129,434,755 bp[2] End 129,474,148 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus testicle lymph node granulocyte blood appendix spleen mucosa of transverse colon left testis right testis Top expressed in stroma of bone marrow granulocyte prefrontal cortex superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell cerebellar cortex tibiofemoral joint perirhinal cortex entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane membrane intracellular anatomical structure Biological process cell-cell signaling cell adhesion intracellular signal transduction positive regulation of T cell activation leukocyte migration positive regulation of cell population proliferation negative regulation of cell population proliferation positive regulation of cell-cell adhesion positive regulation of phagocytosis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 55423 19261 Ensembl ENSG00000089012 ENSMUSG00000037902 UniProt Q9P1W8 P97797 RefSeq (mRNA) NM_001039508 NM_018556 NM_080816 NM_001177646 NM_001177647 NM_001291019 NM_001291020 NM_001291021 NM_001291022 NM_007547 NM_001355158 NM_001355160 RefSeq (protein) NP_001034597 NP_061026 NP_543006 NP_001171118 NP_001277948 NP_001277949 NP_001277950 NP_001277951 NP_031573 NP_001342087 NP_001342089 Location (UCSC) Chr 20: 1.63 – 1.66 Mb Chr 2: 129.43 – 129.47 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.^[7]