CXCR6

C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene.^[5][6][7] CXCR6 has also recently been designated CD186 (cluster of differentiation 186).

AliasesCXCR6, BONZO, CD186, STRL33, TYMSTR, C-X-C motif chemokine receptor 6

External IDsOMIM: 605163; MGI: 1934582; HomoloGene: 38197; GeneCards: CXCR6; OMA:CXCR6 - orthologs

Chr.Chromosome 3 (human)^[1]

End45,948,351 bp^[1]

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CXCR6
Identifiers
Aliases	CXCR6, BONZO, CD186, STRL33, TYMSTR, C-X-C motif chemokine receptor 6
External IDs	OMIM: 605163; MGI: 1934582; HomoloGene: 38197; GeneCards: CXCR6; OMA:CXCR6 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 45,940,933 bp[1] End 45,948,351 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F4|9 74.57 cM Start 123,635,540 bp[2] End 123,640,825 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen lymph node amniotic fluid gallbladder appendix blood tonsil mucosa of transverse colon granulocyte epithelium of colon Top expressed in thymus embryo embryo mesenteric lymph nodes spleen blastocyst blood subcutaneous adipose tissue right kidney duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function C-X-C chemokine receptor activity C-X-C chemokine binding G protein-coupled receptor activity chemokine receptor activity signal transducer activity coreceptor activity C-C chemokine receptor activity chemokine binding C-C chemokine binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane intracellular anatomical structure external side of plasma membrane Biological process viral genome replication chemotaxis chemokine-mediated signaling pathway G protein-coupled receptor signaling pathway inflammatory response signal transduction immune response positive regulation of cytosolic calcium ion concentration calcium-mediated signaling cell chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10663 80901 Ensembl ENSG00000172215 ENSMUSG00000048521 UniProt O00574 Q9EQ16 RefSeq (mRNA) NM_006564 NM_030712 RefSeq (protein) NP_006555 NP_109637 Location (UCSC) Chr 3: 45.94 – 45.95 Mb Chr 9: 123.64 – 123.64 Mb PubMed search [3] [4]
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CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.^[5][6][7][8] It is a minor coreceptor for HIV-1, nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV, CXCR6 may be a major coreceptor.^[8] CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.