CNTRL

Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110.^[5][6]

AliasesCNTRL, CEP1, CEP110, FAN, bA165P4.1, centriolin

External IDsOMIM: 605496; MGI: 1889576; GeneCards: CNTRL

Chr.Chromosome 9 (human)^[1]

End121,177,729 bp^[1]

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CNTRL
Identifiers
Aliases	CNTRL, CEP1, CEP110, FAN, bA165P4.1, centriolin
External IDs	OMIM: 605496; MGI: 1889576; GeneCards: CNTRL
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.2 Start 121,074,660 bp[1] End 121,177,729 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 35,109,492 bp[2] End 35,178,822 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon secondary oocyte ventricular zone bronchial epithelial cell testicle left testis right testis sural nerve sperm monocyte Top expressed in genital tubercle ventricular zone granulocyte spermatocyte tail of embryo thymus mesenteric lymph nodes spermatid spleen blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein tyrosine kinase activity cytoskeletal protein binding Cellular component microtubule organizing center centrosome cytoskeleton membrane cytoplasm cytosol midbody Flemming body centriolar subdistal appendage Biological process cell division cell cycle G2/M transition of mitotic cell cycle peptidyl-tyrosine phosphorylation mitotic cell cycle ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle regulation of cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 11064 26920 Ensembl ENSG00000119397 ENSMUSG00000057110 UniProt Q7Z7A1 A2AL36 RefSeq (mRNA) NM_007018 NM_001330762 NM_001369892 NM_001369893 NM_001369894 NM_001369895 NM_001369896 NM_001290635 NM_012018 NM_030000 NM_001379274 NM_001379275 RefSeq (protein) NP_001317691 NP_008949 NP_001356821 NP_001356822 NP_001356823 NP_001356824 NP_001356825 NP_001277564 NP_036148 NP_001366203 NP_001366204 Location (UCSC) Chr 9: 121.07 – 121.18 Mb Chr 2: 35.11 – 35.18 Mb PubMed search [3] [4]
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This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centriolin.^[6]